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Nefopam,Placebo

8 trials

Sponsors

Faculty of Medicine, Khon Kaen University, Faculty of Medicine, Thammasat University, Phyathai 3 Hospital, Khonkaen University, Research Facilitation Division, Faculty of Medicine Vajira Hospital, Navamindradhiraj University

Conditions

Efficacy of Nefopam 20mg IV during RIRS then Nefopam 80mg IV drip in 24 hr in Opioid consumption difference Nefopam, RIRS, painPain in patients undergoing intra-oral surgery under general anesthesia tonsillectomy, nefopam, parecoxib, intra-oral airway surgeryPostoperative pain in Patients who have anterior cruciate ligament tear and plan to undergo Arthroscopic Anterior cruciate ligament reconstruction surgery Nefopam, Anterior cruciate ligament tear, AACLRPrimary osteoarthritis of the knee Nefopam Total knee arthroplasty Multimodal analgesiaSevere primary osteoarthritis of knee Preemptive analgesia, Multimodal analgesia, Enhanced Recovery After Surgery, Short-stayTo reduce morphine use and morphine related side effect for postoperative pain control after ankle fracture fixation Ankle fracture, nefopam, morphine, postoperative pain, ankle fracture fixationTotal knee arthroplasty Pain Nefopam Total knee arthroplasty Pain Nefopamcatheter related bladder discomfort normal saline 100 ml intravenous drip in 30 min

Phase 2

Analgesic efficacy of nefopam for acute postoperative pain after ankle fracture surgery: triple-blind randomized controlled trial
Active, not recruitingTCTR20240618002
Research Facilitation Division, Faculty of Medicine Vajira Hospital, Navamindradhiraj UniversityTo reduce morphine use and morphine related side effect for postoperative pain control after ankle fracture fixation Ankle fracture, nefopam, morphine, postoperative pain, ankle fracture fixation
Start: 2021-08-01Target: 46Updated: 2026-08-03

Phase 3

Single Preemptive Dose of Intravenous Nefopam Augmenting Multimodal Analgesia for Total Knee Arthroplasty: A Prospective, Triple-Blind, Randomized Controlled Trial
Active, not recruitingTCTR20251224005
Buddhachinaraj hospitalSevere primary osteoarthritis of knee Preemptive analgesia, Multimodal analgesia, Enhanced Recovery After Surgery, Short-stay
Start: 2025-10-01Target: 60Updated: 2026-08-03
Analgesic Efficacy of Nefopam combined with Parecoxib in Patients Undergoing Intraoral Upper Airway Surgery
Active, not recruitingTCTR20260122011
Faculty of Medicine, Chulalongkorn UniversityPain in patients undergoing intra-oral surgery under general anesthesia tonsillectomy, nefopam, parecoxib, intra-oral airway surgery
Start: 2023-07-13Target: 46Updated: 2026-08-03

Phase 4

The effect of single dose Nefopam on postoperative catheter-related bladder discomfort in patients undergoing transurethral resection of prostate: A randomized controlled trial
RecruitingTCTR20191217005
Faculty of Medicine, Khon Kaen Universitycatheter related bladder discomfort normal saline 100 ml intravenous drip in 30 min
Start: 2019-12-15Target: 74Updated: 2026-08-03
Efficacy of Nefopam as a Multimodal Analgesic Agent in Acute Post-Operative Pain Control After Total Knee Arthroplasty – A Randomized Control Trial
RecruitingTCTR20200410009
Faculty of Medicine, Thammasat UniversityPrimary osteoarthritis of the knee Nefopam Total knee arthroplasty Multimodal analgesia
Start: 2020-04-08Updated: 2026-08-03
Additional nefopam reduces postoperative pain after primary total knee arthroplasty: a randomized controlled trial
Active, not recruitingTCTR20220814002
Phyathai 3 HospitalTotal knee arthroplasty Pain Nefopam Total knee arthroplasty Pain Nefopam
Start: 2020-03-01Target: 80Updated: 2026-08-03
Analgesic efficacy of Nefopam after Arthroscopic Anterior cruciate ligament reconstruction surgery: A Prospective, Tripple-blind, randomized controlled trial
Active, not recruitingTCTR20240412003
Khonkaen UniversityPostoperative pain in Patients who have anterior cruciate ligament tear and plan to undergo Arthroscopic Anterior cruciate ligament reconstruction surgery Nefopam, Anterior cruciate ligament tear, AACLR
Start: 2024-05-02Target: 70Updated: 2026-08-03
Effect of post operative intravenous nefopam on opioid consumption after retrograde intrarenal surgery of renal stone (RIRS)
Active, not recruitingTCTR20241201005
Division of Urological Surgery, Faculty of Medicine, Siriraj hospitalEfficacy of Nefopam 20mg IV during RIRS then Nefopam 80mg IV drip in 24 hr in Opioid consumption difference Nefopam, RIRS, pain
Start: 2025-01-06Target: 128Updated: 2026-08-03