Severe primary osteoarthritis of knee Preemptive analgesia, Multimodal analgesia, Enhanced Recovery After Surgery, Short-stay
Conditions
Interventions
nefopam 20 mg mix with D5W 100 ml iv drip in 30 minutes before incision,D5W 100 ml iv drip in 30 minutes before incision
Experimental Drug,Placebo Comparator Drug
Sponsors
Buddhachinaraj hospital
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Patient diagnosed with primary knee OA Kellgrence-Lawrence stage 3,4 and scheduled for unilateral primary TKA 2.Underwent TKA with fixed-bearing posterior stabilized 3.Age 55-85 years old 4.ASA class I-III
Exclusion criteria
Exclusion criteria: 1.History of epilepsy, glaucoma, BPH 2.Severe hepatic or renal dysfunction 3.Use of MAOIs, SSRIs, or SNRIs 4.Allergy to nefopam or related drugs 5.Inability to undergo spinal anesthesia or adductor canal block 6.Previous surgery on the same knee 7.BMI more than 35 8.Cognitive impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analog scale 24 hours Regression analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| morphine consumption 48 hours Regression analysis,Incidence of postoperative nausea and vomiting (PONV) 48 hours Risk regression model,Incidence of tachycardia 48 hours Risk regression model,Functional recovery (ROM, Time to first ambulation, TUG, Time to discharge) 48 hours Regression analysis,Oxford Knee Score 6 weeks Regression analysis,Patient satisfaction At discharge Regression analysis | — |
Countries
Thailand
Contacts
Public ContactRatchaphon Khasemsiri
Buddhachinaraj hospital
Outcome results
None listed