Efficacy of Nefopam 20mg IV during RIRS then Nefopam 80mg IV drip in 24 hr in Opioid consumption difference Nefopam, RIRS, pain
Conditions
Interventions
Nefopam 20 mg + NSS 100 ml iv drip in 30 min during cystoscope then Nefopam 80 mg + NSS 500 ml iv drip in 24 hr ,NSS 100 ml iv drip in 30 min during cystoscopy then NSS 500 ml iv drip in 24 hr
Active Comparator Drug,Placebo Comparator Drug
Sponsors
Division of Urological Surgery, Faculty of Medicine, Siriraj hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with kidney stones undergoing retrograde intrarenal surgery (RIRS) at Siriraj Hospital 2. Patients classified as American Society of Anesthesiologists (ASA) physical status class I, II, or III. 3. Patients capable of using patient-controlled analgesia (IV PCA) for postoperative pain management. 4. Patients with proficient Thai language skills, including reading and writing.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of allergy to opioids or nefopam. 2.Patients with contraindications to nefopam use, including: 2.1 History of seizures or epilepsy. 2.2 Risk of acute urinary retention. 2.3 Acute angle-closure glaucoma. 2.4 Pregnancy (based on menstrual history) or breastfeeding. 2.5 Renal impairment with creatinine clearance < 20 ml/min. 2.6 Cirrhosis with Child-Pugh class C. 2.7 Use of monoamine oxidase inhibitors within 30 days. 2.8 History of long-term opioid use or chronic substance abuse prior to surgery. 3.Patients with abnormal kidney structures, such as horseshoe kidney or abnormal collecting systems. 4.Patients with a history of chronic pain or regular use of analgesic medications. 5.Patients with incomplete or missing data required for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| post-operative opioid consumption 3, 6, 24, 48 hr post-operative mg,post-operative pain every vital sign measuring point, 24 and 48 hr post-operative visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| post-operative pain every vital sign measuring point, 24 and 48 hr post-operative visual analog scale,length of stay during admission day,complication during admission time | — |
Countries
Thailand
Contacts
Public ContactEkkarin Chotikawanich
Mahidol University
Outcome results
None listed