Primary osteoarthritis of the knee Nefopam Total knee arthroplasty Multimodal analgesia
Conditions
Interventions
The volunteers will be given nefopam 80mg + 5%DW 500 ml intravenous drip in 24h from time 0 (at PACU) to 24 h post-
op,The volunteers will be given 5%DW 500 ml intravenous drip in 24h from time 0 (at PACU) to 24 h post-
Experimental Drug,Placebo Comparator No treatment
Sponsors
Faculty of Medicine, Thammasat University
Faculty of Medicine,
Thammasat University
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patient diagnosed primary OA knee and needed surgery Age 55-80 years ASA class I-III Understand the protocol and volunteered to join the study
Exclusion criteria
Exclusion criteria: Cannot undertaken spinal block and adductor canal block Allergy to study drugs (nefopam & other drugs in standard order) Have previous surgery on the same side of TKA knee (such as knee arthroscopy, UKA, HTO, fracture fixation) Renal insufficiency (CCr <30ml/min) History of convulsive disorder History of stroke or intracranial surgery Abnormal liver function (Child-Pugh score C) History of glaucoma, BPH Taking MAOIs, TCAs, SSRIs, SNRIs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 100mm VAS 6,12,18,24,30,36,48 h post operative at rest and motion patient will mark the VAS on the 100mm line, left end = no pain, right end = unimaginable pain | — |
Secondary
| Measure | Time frame |
|---|---|
| Morphine consumption 0-48 h post-op mg,Adverse effect 0-48 h post-op n, percentage,Range of motion 24,48 h post-op degree, line from greater trochanter to knee to line along anterior tibia,Timed up and go test 48h post-op second,Time to walk from post-op to discharge hours post-op,Time to discharge when volunteer has VAS 12 h hours,sedation score 12, 24, 36,48 h post-op 0-3 ,satisfactory score 12, 24, 36,48 h post-op 0-3 | — |
Countries
Thailand
Contacts
Public ContactPiya Pinsornsak
Department of Orthopaedics, Faculty of Medicine, Thammasat University
Outcome results
None listed