Pain in patients undergoing intra-oral surgery under general anesthesia tonsillectomy, nefopam, parecoxib, intra-oral airway surgery
Conditions
Interventions
Thirty minutes before completion of surgery, patients in the nefoapm group received nefopam 20 mg (2 mL) diluted with 0.9 % isotonic saline to a total volume of 100 mL,Thirty minutes before completion
Active Comparator Drug,Placebo Comparator Drug
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 to 65 years, diagnosed of chronic tonsillitis, chronic hypertrophy of the tonsils or obstructive sleep apnea 2. American Society of Anesthesiologists (ASA) physical status I to III 3. Scheduled for elective intra-oral upper airway surgery (tonsillectomy with or without UPPP) under general anesthesia
Exclusion criteria
Exclusion criteria: 1. Patients with co-morbidities including ischemic heart disease, cardiac conduction disturbance, or hepatorenal diseases 2. History of long-term use of certain medications such as monoamine oxidase inhibitors or receiving chronic pain treatment 3. History of allergy or contraindications to any drugs used in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain 24 hours after surgery cumulative morphine consumption | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain At recovery room, 1, 6, 12, and 24 hours after surgery Visual analog scale pain score,Adverse effects At recovery room, 1, 6, 12, and 24 hours after surgery Incidence | — |
Countries
Thailand
Contacts
Public ContactAthitarn Earsakul
Faculty of Medicine, Chulalongkorn University
Outcome results
None listed