The effect of single dose Nefopam on postoperative catheter-related bladder discomfort in patients undergoing transurethral resection of prostate: A randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20191217005

Enrollment

Registered

2019-12-17

Start date

2019-12-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

catheter related bladder discomfort normal saline 100 ml intravenous drip in 30 min

Interventions

nefopam 20 mg + normal saline up to 100 ml intravenous drip in 30 min,normal saline

Active Comparator Drug,Placebo Comparator No treatment

nefopam,placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patient undergoing Transurethral resection of prostate (TUR-P) under spinal anesthesia ASA physical status class I-III able to make decision and communicate on urinary catheter traction at least 12 hours after operation

Exclusion criteria

Exclusion criteria: known allergic to nefopam or morphine epilepsy heart failure arrhythmia liver disease (total bilirubin>1.2 mg/dl AST>80 U/L ALT>66 U/L ALP>240 U/L) Chronic kidney disease (GFR40 kg/m2) psychological illness chronic pain

Design outcomes

Primary

Measure	Time frame
degree of catheter-related bladder discomfort at 6 hour after operation patient report	—

Secondary

Measure	Time frame
morphine consumption 24 hour after operation medical record	—

Countries

Thailand

Contacts

Public ContactNutchanok Khampitak

Khon Kaen University

miw.khampitak@gmail.com0868789316

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026

The effect of single dose Nefopam on postoperative catheter&#45;related bladder discomfort in patients undergoing transurethral resection of prostate: A randomized controlled trial