To reduce morphine use and morphine related side effect for postoperative pain control after ankle fracture fixation Ankle fracture, nefopam, morphine, postoperative pain, ankle fracture fixation
Conditions
Interventions
Nefopam 20 mg with normal saline solution 98 ml intravenous drip in 1 hour after surgical wound closure
then Nefopam 80 mg with normal saline solution 492 ml intravenous drip 20 ml/hr within 24 hours,
Experimental Drug,Placebo Comparator No treatment
Sponsors
Research Facilitation Division, Faculty of Medicine Vajira Hospital, Navamindradhiraj University
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 15-70 years old 2. American Society of Anesthesiologists (ASA) physical status) class I, II and III 3. Undergo ankle fracture fixation
Exclusion criteria
Exclusion criteria: 1. Contraindication for nefopam 2. History of allergic to any drugs in study protocol 3. History of opioids use within 3 months 4. Contraindication for spinal anesthesia 5. Peripheral neuropathies 6. Multi-organ injuries 7. Cognitive impairment 8. Pregnancy 9. Refuse to join study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain by visual analog scale 48 hours postoperative visual analog scale | — |
Secondary
| Measure | Time frame |
|---|---|
| morphine consumption 48 hours Total dose of morphine ,Time to first dose of morhpine 0-48 hours Time to first dose of morhpine,side effects of morphine 48 hours side effects of morphine,side effects of nefopam 48 hours side effects of nefopam | — |
Countries
Thailand
Contacts
Public ContactSamrit Tanya
Faculty of Medicine Vajira Hospital, Navamindradhiraj University
Outcome results
None listed