PPI

DRUG19 trials

Sponsors

The Jikei University School of Medicine, University of Southern California, XenoPort, Inc., EndoGastric Solutions, Soonchunhyang University Hospital

Conditions

Acute Coronary SyndromeBarrett's EsophagusBenign Neoplasm of StomachCoronary Artery DiseaseDeliriumDietary SupplementsErectile DysfunctionErectile Dysfunction Due to Venous Disorder

Phase 1

Relative Bioavailability and Drug-drug Interaction Study With MT-7117 and a Proton Pump Inhibitor

CompletedNCT03688022

Tanabe Pharma America, Inc.Healthy Volunteer

Start: 2018-10-25End: 2018-12-22Updated: 2023-05-15

A Study to Evaluate the Effect of Food, Formulation, and a Proton Pump Inhibitor (PPI) on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-003)

CompletedNCT06619314

Merck Sharp & Dohme LLCHealthy

Start: 2023-09-20End: 2023-11-25Updated: 2026-02-11

Phase 2

A Study to Evaluate the Efficacy and Safety of Arbaclofen Placarbil (XP19986) as Adjunctive Therapy in Subjects With Gastroesophageal Reflux Disease (GERD)

CompletedNCT00978016

XenoPort, Inc.Gastroesophageal Reflux Disease

Start: 2009-09-30End: 2010-12-31Updated: 2021-02-21

A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD)

CompletedNCT02637557

Ironwood Pharmaceuticals, Inc.Gastroesophageal Reflux Disease

Start: 2016-03-01End: 2017-04-26Updated: 2019-10-15

Phase 4

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy

RecruitingNCT04416581

Duk-Woo Park, MDAcute Coronary Syndrome, Coronary Artery Disease, Myocardial Infarction +1

Start: 2021-05-12End: 2027-12-31Target: 3320Updated: 2025-12-30

Unknown Phase

PPI Versus Placebo in Severe Functional Heartburn

WithdrawnNCT00222989

University of Southern CaliforniaGERD

Start: 2003-10-31End: 2100-12-01Updated: 2017-04-14

The EndoGastric Solutions TEMPO Trial

CompletedNCT01647958

EndoGastric SolutionsGastroesophageal Reflux Disease (GERD)

Start: 2012-06-01End: 2017-12-01Updated: 2020-11-23

Surgicel® Fibrillar for Delayed Bleeding After ESD

CompletedNCT01758965

Soonchunhyang University HospitalBenign Neoplasm of Stomach, Malignant Neoplasm of Stomach

Start: 2012-12-31End: 2013-12-31Updated: 2014-05-13

Pepsinogen measurement of middle ear effusion in for treatment-resistant otitis media of infants

Active, not recruitingJPRN-UMIN000013459

The Jikei University School of MedicineTreatment-resistant otitis media of infants

Start: 2014-04-01Target: 40Updated: 2025-07-18

The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients

Taichung Tzu Chi HospitalBarrett's Esophagus, Non-erosive Reflux Disease

Start: 2014-05-31End: 2016-07-31Target: 120Updated: 2014-11-20

Treatment Response of Maintenance Dose of Proton Pump Inhibitor in Patients With Nonerosive Gatroesophageal Reflux Disease

CompletedNCT03436914

Yonsei UniversityNon-erosive Gatroesophageal Reflux Disease

Start: 2018-09-01End: 2019-10-18Updated: 2020-01-02

A New System for GERD Diagnosis and Treatment

Capital Medical UniversityGERD

Start: 2019-02-01End: 2021-07-01Target: 200Updated: 2019-02-05

Dietary Supplement With and Without a Probiotic

CompletedNCT04433208

Prolacta BioscienceHealthy Adult Subjects

Start: 2020-03-13End: 2020-12-02Updated: 2025-03-18

The Effect of a Plant Protein Isolate on Muscle Protein Synthesis in Humans at Rest and After Resistance Exercise

CompletedNCT05020808

University of LimerickDietary Supplements, Exercise, Metabolism

Start: 2021-09-14End: 2022-06-20Updated: 2022-06-22

Delirium Related to Proton Pump Inhibitors Use

CompletedNCT05815550

University Hospital, CaenDelirium, Hyponatremia, Proton Pump Inhibitor Adverse Reaction

Start: 2022-02-09End: 2022-02-10Updated: 2025-03-26

Shaeer's Vein Ligation-I: Internal Pudendal Vein Sub-Gluteal Ligation For Veno Occlusive Erectile Dysfunction

Kasr El Aini HospitalErectile Dysfunction

Start: 2024-01-31End: 2025-02-28Target: 60Updated: 2023-11-08

Shaeer's Vein Ligation-II: Internal Pudendal Vein Perineal Ligation For Veno Occlusive Erectile Dysfunction

Kasr El Aini HospitalErectile Dysfunction, Erectile Dysfunction Due to Venous Disorder

Start: 2024-01-31End: 2025-02-28Target: 60Updated: 2023-11-08

Emulation of Randomized Clinical Trial in Cardiovascular Disease

RecruitingNCT06241833

Samsung Medical CenterCoronary Artery Disease, Myocardial Infarction

Start: 2023-05-30End: 2025-12-31Target: 118420Updated: 2024-03-26

Efficacy of Nitazoxanide Based Therapy vs Standard Triple Therapy in H-pylori in Children

CompletedNCT07086937

Muhammad Aamir LatifHelicobacter Pylori Infection

Start: 2025-01-01End: 2025-06-30Updated: 2025-07-25

Related Papers

Potassium-competitive acid blocker vs proton-pump inhibitor in patients receiving antithrombotic therapy who are at high risk for gastrointestinal bleeding: Rationale and design of the randomized PROTECT- HBR trial.

2025-04-04

Effects of proton pump inhibitors on gastrointestinal bleeding and cardiovascular outcomes in myocardial infarction patients treated with DAPT

EuroIntervention2025-02-014 citations

Association between exposure to proton pump inhibitors and delirium: a descriptive and disproportionality analysis of VigiBase

BMJ Open2024-10-011 citations

Absorption, metabolism, and excretion of [<scp><sup>14</sup>C</scp>]dersimelagon, an investigational oral selective melanocortin 1 receptor agonist, in preclinical species and healthy volunteers

Pharmacology Research & Perspectives2023-04-208 citations

IW-3718 Reduces Heartburn Severity in Patients With Refractory Gastroesophageal Reflux Disease in a Randomized Trial

Gastroenterology2020-02-2146 citations

Evaluation and Validation of the Modified Reflux Symptom Questionnaire–Electronic Diary in Patients With Persistent Gastroesophageal Reflux Disease

Clinical and Translational Gastroenterology2020-01-012 citations

Randomised clinical trial: arbaclofen placarbil in gastro-oesophageal reflux disease--insights into study design for transient lower sphincter relaxation inhibitors.

2013-05-3022 citations