PPI Versus Placebo in Severe Functional Heartburn

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00222989

Enrollment

Registered

2005-09-22

Start date

2003-10-31

Completion date

2100-12-01

Last updated

2017-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

GERD

Keywords

GERD, PPI, Functional heartburn

Brief summary

Proton Pump Inhibitors are no better than placebo in relieving GERD symptoms in patients with functional Heartburn.

Interventions

DRUGPPI

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Heartburn twice a week for at least 2 years. Normal EGD and 24hr pH study.

Exclusion criteria

* \<18yrs of age,pregnant, unable or unwilling to give consent, allergic to PPI, previous gastric or esophageal surgery, past hx of erosive GERD, unwilling or unable to stop acid suppression meds

Design outcomes

Primary

Measure	Time frame
Difference in GERD controll PPI vs Placebo based on a validated GERD questionnarir.	1 year

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026