Helicobacter Pylori Infection
Conditions
Brief summary
This study aimed at comparing the efficacy of nitazoxanide-based triple therapy versus standard triple therapy for eradication of Helicobacter pylori infection in children at a tertiary care hospital.
Detailed description
The findings could guide clinical practice and influence guidelines, improving the management of H. pylori infections in the pediatric population. Not much local data also exists comparing the effectiveness of adding nitazoxanide to the standard triple therapy in children with H. pylori infection. If nitazoxanide-based therapy proves superior, it could reduce the incidence of antibiotic resistance associated with standard triple therapy.
Interventions
DRUGNitazoxanide
Children were given nitazoxanide, PPI, and clarithromycin for 14 days.
DRUGMetronidazole
Children received MTZ, PPI, and clarithromycin for 14 days.
DRUGPPI
Children were given omeprazole for 14 days.
DRUGClarithromycin
Children were given clarithromycin for 14 days.
Sponsors
Muhammad Aamir Latif
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* Any gender * Aged 2 to 12 years * With symptoms like abdominal pain, nausea, vomiting, or other related gastrointestinal symptoms * Diagnosed with H. pylori based on urea breath test
Exclusion criteria
* Liver cirrhosis * Renal impairment * Previous gastric or duodenal surgery or malignancy * History of receiving H. pylori treatment * Past 6 weeks history of using antacids, H2 receptor antagonists, anticoagulants, or antibiotics
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Treatment efficacy | 6 weeks | The patients were considered clinically cured if they had a negative H. pylori stool Ag test and were free of symptoms at 6 weeks after starting treatment, or otherwise failure was labeled. |
Countries
Pakistan
Outcome results
None listed