Non-erosive Reflux Disease, Barrett's Esophagus
Conditions
Keywords
Ryodoraku, Meridian energy, Heart rate variability, Autonomic Nervous System, GERD
Brief summary
Gastroesophageal reflux disease(GERD) mainly related to the reflux of stomach content induced by the dysfunction of lower esophageal sphincter. Proton pump inhibitors (PPI) can effectively block gastric acid secretion but the drug reactions and the degree of improvement in symptoms are sometimes unpredictable. The aim of this study is to investigate the association between the clinical efficacy of PPI in patients with GERD and the personal physical status by Ryodoraku and ANSWatch.
Detailed description
Gastroesophageal reflux disease(GERD) is a common disease, mainly related to the reflux of stomach content induced by the dysfunction of lower esophageal sphincter. The common symptoms of GERD are heartburn, acid regurgitation, chest pain and globus hystericus. The methods to treat GERD are changes of lifestyle, pharmacotherapy, antireflux surgery and endoscopy. Proton pump inhibitors (PPI) can effectively block gastric acid secretion and promote the repair of esophagus, but the drug reactions and the degree of improvement in symptoms are sometimes unpredictable. Recently there are many instruments used to analyze personal physical status. Meridian energy analysis device ( Ryodoraku ) is used to assess the energy of meridian system by analysis of resistance of the skin surface, as well as the wrist-worn heart rate monitor (ANSWatch) used to assess the autonomic nervous system by analysis of heart rate variability. Therefore, the aim of this study is to investigate the association between the clinical efficacy of PPI in patients with GERD and the personal physical status by Ryodoraku and ANSWatch. Investigators will recruit 120 patients with GERD in clinic who have to receive PPIs for four weeks and assess each volunteer before and after taking the medication. Assessment methods : 1. ANSWatch to assess the autonomic nervous system, 2. Ryodoraku to assess the energy of meridian system, 3. Upper gastrointestinal endoscopy to assess the grade of reflux esophagitis, 4. gastroesophageal reflux disease questionnaire to assess the severity of GERD. Investigators analysed and compared the database from the assessments between before and after taking the medication. Investigators anticipate to substantiate that the changes of Ryodoraku and ANSWatch are good predictors for the clinical efficacy of PPI in patients with GERD.
Interventions
DEVICERyodoraku
Ryodoraku to assess the energy of meridian system for each patient before and after taking the medication
DEVICEANSWatch
ANSWatch to assess the autonomic nervous system for each patient before and after taking the medication
DEVICEUGI endoscopy
UGI endoscopy to assess the grade of reflux esophagitis for each patient before and after taking the medication
OTHERGerdQ
GerdQ to assess the severity of GERD for each patient before and after taking the medication
DRUGPPI
Sponsors
Taichung Tzu Chi Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* male or female * age of 20-75 years * patients with GERD who have to receive PPIs for four weeks
Exclusion criteria
* Suffering from peptic ulcer, gallstones, cancer, and Barrett's esophagus * previously underwent the esophagus, stomach or duodenum surgery * Lactating women or pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gastroesophageal reflux disease questionnaire | four weeks | To assess the severity of GERD |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Upper gastrointestinal endoscopy | four weeks | To assess the grade of reflux esophagitis |
Countries
Taiwan
Outcome results
None listed