Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis (SMART-JIA)

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

EU CTIS

Registry ID

CTIS2025-520923-25-00

Enrollment

Registered

2026-02-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Juvenile Idiopathic Arthritis

Brief summary

Minimal disease activity (MiDA) at Month 6 as assessed by the cJADAS10 less than or equal to 5

Detailed description

PROMIS® pain interference at Month 6, PROMIS® fatigue at Month 6, PROMIS® mobility at Month 6, Change in arthritis disease activity (cJADAS10 and JIA American College of Rheumatology Pediatric 70 [ACR 70]) at Month 6, Change in arthritis disease activity (cJADAS10) at Month 12

Interventions

DRUGORENCIA 50 mg solution for injection in pre-filled syringe

DRUGORENCIA 125 mg solution for injection in pre-filled syringe

DRUGORENCIA 87.5 mg solution for injection in pre-filled syringe

DRUGTyenne 162mg/0.9ml solution for injection in pre-filled syringe

DRUGEnbrel 25 mg solution for injection in pre-filled syringe

DRUGEnbrel 50 mg solution for injection in pre-filled syringe

DRUGXELJANZ 1 mg/mL oral solution

DRUGHumira 40 mg solution for injection in pre-filled syringe

DRUGXELJANZ 5 mg film-coated tablets

DRUGHumira 20 mg solution for injection in pre-filled syringe

Eligibility

Sex/Gender

All

Age

0 Years to 17 Years

Design outcomes

Primary

Measure	Time frame
Minimal disease activity (MiDA) at Month 6 as assessed by the cJADAS10 less than or equal to 5	—

Secondary

Measure	Time frame
PROMIS® pain interference at Month 6, PROMIS® fatigue at Month 6, PROMIS® mobility at Month 6, Change in arthritis disease activity (cJADAS10 and JIA American College of Rheumatology Pediatric 70 [ACR 70]) at Month 6, Change in arthritis disease activity (cJADAS10) at Month 12	—

Outcome results

None listed

Source: EU CTIS · Data processed: Feb 12, 2026