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ORENCIA 125 mg solution for injection in pre-filled syringe

DRUG8 trials

Sponsors

Centre Hospitalier Universitaire De Montpellier, Universitaetsklinikum Erlangen AöR, Queen Mary University Of London, Charite Universitaetsmedizin Berlin KöR, IRCCS Istituto Giannina Gaslini

Conditions

Adults patients suffering from rheumatoid arthritis and in adequate response to one or two targeted treatments.Juvenile Idiopathic ArthritisJuvenile idiopathic arthritisPsoriatic arthritisRheumatoid ArthritisRheumatoid arthritis

Phase 1

Plasma cell depletion as an approach to reset autoimmunity in rheumatoid arthritis
RecruitingCTIS2024-511536-27-00
Charite Universitaetsmedizin Berlin KöRRheumatoid arthritis
Start: 2025-03-11Target: 23Updated: 2025-08-11

Phase 3

Efficacy of a sequential treatment strategy in Rheumatoid Arthritis. A randomized controlled trial with an independent efficacy assessor.
RecruitingCTIS2022-500234-29-00
Centre Hospitalier Universitaire De MontpellierRheumatoid Arthritis
Start: 2022-11-28Target: 210Updated: 2025-10-01
A prospective, randomized, controlled, open label, assessor-blinded, parallel-group Phase III clinical trial to evaluate the impact of tapering systemic immunosuppressive therapy in a treat-to-target approach on maintaining minimal disease activity in adult subjects with psoriatic arthritis
RecruitingCTIS2023-508251-39-00
Universitaetsklinikum Erlangen AöRPsoriatic arthritis
Start: 2020-09-18Target: 370Updated: 2026-01-20
Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis (SMART-JIA)
Not yet recruitingCTIS2025-520923-25-00
Duke Clinical Research InstituteJuvenile Idiopathic Arthritis
Target: 30Updated: 2026-02-11

Phase 4

ABATACEPT VERSUS TOCILIZUMAB BY SUBCUTANEOUS ADMINISTRATION FOR THE TREATMENT OF RHEUMATOID ARTHRITIS IN TARGETED TREATMENT INADEQUATE RESPONDER PATIENTS: A RANDOMIZED, OPENLABELED, SUPERIORITY TRIAL. -SUNSTAR-
Active, not recruitingCTIS2024-515600-39-00
Groupement Des Hopitaux De L'Institut Catholique De Lille, Groupement Des Hopitaux De L'Institut Catholique De LilleAdults patients suffering from rheumatoid arthritis and in adequate response to one or two targeted treatments.
Start: 2018-01-23Target: 224Updated: 2024-07-31
Toward personalized medicine to guide drug withdrawal in children with juvenile idiopathic arthritis in clinical remission: a randomized clinical trial comparing early versus late drug withdrawal combining imaging and multi-Omics.
RecruitingCTIS2024-514732-24-00
IRCCS Istituto Giannina GasliniJuvenile idiopathic arthritis
Start: 2025-04-28Target: 328Updated: 2025-08-26
The 3TR Molecular PAthobiology and PRecision Therapy iN EaRly Rheumatoid Arthritis Study
RecruitingCTIS2024-511470-79-00
Queen Mary University Of LondonRheumatoid Arthritis
Start: 2025-08-14Target: 182Updated: 2025-03-24
Optimising Arthritis Strategies in Elderly patients (≥70 years) with rheumatoid arthritis in sustained low disease activity (the OASE study): A Prospective Target Trial Emulation Study Evaluating Tapering of Disease-Modifying Anti-Rheumatic Drugs vs. Usual Care Based on Patient Preference
Not yet recruitingCTIS2026-525221-21-01
Aalborg University Hospital, Aalborg University HospitalRheumatoid arthritis
Target: 180Updated: 2026-07-06