Humira 40 mg solution for injection in pre-filled syringe
Sponsors
Abbvie Deutschland GmbH & Co. KG, AbbVie Deutschland GmbH & Co. KG, Bristol-Myers Squibb Services Unlimited Company, Groupe D'etude Therapeutique Des Affections Inflammatoires Du Tube Digestif, Universitair Medisch Centrum Groningen
Conditions
Arthritis rheumatoidInflammatory Bowel Disease (IBD)Inflammatory Bowel Disease (IBD)Juvenile Idiopathic ArthritisJuvenile Psoriatic ArthritisJuvenile idiopathic arthritisRheumatoid ArthritisRheumatoid arthritis
Phase 1
Investigating the safety, feasibility, and optimal dose of fluorescently labeled Adalimumab-680LT for visualizing drug targeting in Inflammatory Bowel Diseases.
CompletedCTIS2023-508391-11-00
Start: 2024-03-21End: 2026-01-06Target: 18Updated: 2024-02-21
Dual wavelength fluorescence imaging using fluorescently labelled adalimumab and risankizumab for visualizing drug targeting in Inflammatory Bowel Diseases (VOYAGER)
Not yet recruitingCTIS2025-521420-30-00
Target: 30Updated: 2026-01-06
Phase 2
Phase 3
A Phase 3, Randomized, Double-Blind Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Subjects with Moderately to Severely Active Rheumatoid Arthritis Who are on a Stable Background of Methotrexate (MTX) and Who Have an Inadequate Response to MTX (MTX-IR)
Active, not recruitingCTIS2022-501017-31-00
Start: 2016-05-10Target: 489Updated: 2025-06-02
A Phase 3b/4 Randomized, Double-Blind, Double-Dummy, Active-Comparator Controlled Study, Comparing the Efficacy and Safety of Upadacitinib Versus Adalimumab in Subjects with Moderate to Severe Rheumatoid Arthritis on a stable background of MTX and who had an Inadequate Response or Intolerance to a Single TNF Inhibitor (SELECT- SWITCH)
Active, not recruitingCTIS2022-502578-18-00
Start: 2023-11-07Target: 165Updated: 2025-09-16
A Randomized, Head-to-head, Single-blind Study to Compare the Response to Treatment with Subcutaneous Abatacept vs Adalimumab, on Background Methotrexate, in Adults with Early, Seropositive Rheumatoid Arthritis Who Have "Shared Epitope" HLA Class II Risk Alleles and Have an Inadequate Response to Methotrexate
Active, not recruitingCTIS2023-506450-20-00
Start: 2021-11-05Target: 141Updated: 2025-12-10
A Multi-Center, Open-Label Study of the Human Anti-TNF Monoclonal Antibody Adalimumab to Evaluate Long-Term Safety and Tolerability of Repeated Administration of Adalimumab in Pediatric Subjects with Ulcerative Colitis Who Completed the Study M11-290
CompletedCTIS2023-504711-32-00
Start: 2015-11-24End: 2025-04-08Target: 46Updated: 2025-06-13
Open-label, randomized, assessor-blinded, efficacy, safety, tolerability, and pharmacokinetics study of subcutaneous risankizumab with an adalimumab reference arm in children with active juvenile psoriatic arthritis
RecruitingCTIS2023-506026-36-00
Start: 2024-04-29Target: 24Updated: 2025-09-29
Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis (SMART-JIA)
Not yet recruitingCTIS2025-520923-25-00
Target: 30Updated: 2026-02-11
Phase 4
A multi-center, open, randomized, 18-month, parallel-group, superiority study to compare the effect of proactive therapeutic drug monitoring versus standard of care with regards to maintenance of sustained disease control without flare in adults with rheumatoid arthritis treated with a subcutaneous tumor necrosis factor inhibitor
RecruitingCTIS2023-510184-35-00
Start: 2024-08-20Target: 410Updated: 2025-09-12
An open-label randomized trial COmparing staNdard of care versus Treat to
target with telemonitoRing and patient education in patients with ulcerative
cOlitis initiating adalimumab : The CONTROL trial
RecruitingCTIS2023-507256-76-00
Start: 2020-01-14Target: 238Updated: 2024-11-08
Design and evaluation of an individualized biodrug tapering strategy based on biodrug dosage: the MONITORA study_STEP1
RecruitingCTIS2024-514313-35-00
Start: 2024-12-03Target: 60Updated: 2025-12-09
PeRsonalIzed MEdicine in Rheumatoid Arthritis (PRIMERA trial): a multicenter, open-label, randomized controlled trial comparing usual care with a tailor-made approach
Not yet recruitingCTIS2024-511530-12-01
Target: 300Updated: 2024-10-01
Toward personalized medicine to guide drug withdrawal in children with juvenile idiopathic arthritis in clinical remission: a randomized clinical trial comparing early versus late drug withdrawal combining imaging and multi-Omics.
RecruitingCTIS2024-514732-24-00
Start: 2025-04-28Target: 328Updated: 2025-08-26
Evaluation of a therapeutic de-eScalation strategy based on therapeutic drug MOnitOring in chronic non-infectious uveitis Treated witH adalimumab
Not yet recruitingCTIS2023-509733-39-00
Target: 320Updated: 2025-04-28