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CLOXACILLIN

DRUG13 trials

Sponsors

Region Oestergoetland, Rigshospitalet, Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla, Assistance Publique Hopitaux De Paris, Centre Hospitalier Universitaire De Nimes

Conditions

Bacteremia Due to Methicillin Susceptible Staphylococcus AureusCatheter related bloodstream infections due to Staphylococcus aureusDouble Lumen InfectionHemodialysisPatients with an infection of the osteosynthesis material implanted after a long bone fracturePeriprosthetic joint infectionPyogenic vertebral osteomyelitisSepsis

Phase 2

Phase 3

Staphylococcus Aureus Bacteremia Antibiotic Treatment Options
CompletedNCT01792804
Heinrich-Heine University, DuesseldorfStaphylococcus Aureus Infection
Start: 2013-12-31End: 2020-03-26Updated: 2020-05-27
Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus.
TerminatedNCT01875263
Fundación Pública Andaluza Progreso y SaludStaphylococcus
Start: 2013-05-31End: 2014-11-30Updated: 2015-08-07
Efficacy and safety of different antimicrobial DURATions for the treatment of Infections associated with Osteosynthesis Material implanted after long bone fractures (DURATIOM). Phase 3 pragmatic multicenter open labelled randomized trial.
Not yet recruitingCTIS2023-508442-18-00
Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De SevillaPatients with an infection of the osteosynthesis material implanted after a long bone fracture, who are treated by surgical debridement with retention of the implant plus targeted antimicrobial therapy or by surgical debridement with removal of the material. These patients have the osteosynthesis material implanted to stabilize and help heal the fracture and who meet the criteria for Infections associated with the osteosynthesis material. -arm without/with removal MO: 256/108pac (364pac)
Target: 364Updated: 2025-04-11
Randomized open-label controlled trial evaluating a single-dose intravenous Dalbavancin versus standard antibiotic therapy during catheterrelated bloodstream infections due to Staphylococcus aureus [DALICATH]
RecruitingCTIS2024-514952-34-00
Assistance Publique Hopitaux De ParisCatheter related bloodstream infections due to Staphylococcus aureus
Start: 2023-06-23Target: 406Updated: 2025-04-23

Phase 4

Kan skattning av njurfunktion (eGFR) förutsäga vilka patienter med S. aureus-bakteremi som behöver justerad dosering via monitorering av kloxacillinkoncentrationer i plasma (TDM)?
RecruitingCTIS2023-505148-20-00
Region OestergoetlandStaphyloccus aureus bacteremia
Start: 2024-06-01Target: 90Updated: 2023-11-24
Early shift to oral antibiotic treatment of pyogenic vertebral osteomyelitis – a open label non-inferiority randomized nationwide study.
RecruitingCTIS2023-507617-96-01
RigshospitaletPyogenic vertebral osteomyelitis
Start: 2024-02-14Target: 530Updated: 2025-01-08
Comparison of Cloxacillin and Benzylpenicillin in Penicillin Susceptible S. Aureus Bacteraemia
RecruitingNCT06726395
Region SkaneStaphylococcal Bacteraemia, Staphylococcus Aureus Bacteraemia, Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia) +1
Start: 2025-03-10End: 2028-07-31Target: 420Updated: 2025-03-12
Aminoglycosides in early sepsis (AGES): A randomized pragmatic clinical trial comparing gentamicin and narrow spectrum betalactams to broad spectrum betalactams as empirical treatment in patients with suspected sepsis
Not yet recruitingCTIS2024-519797-39-00
Akershus University HospitalSepsis
Target: 2000Updated: 2025-12-19
The DALBA-study Introduction of the antibiotic dalbavancin in orthopaedic surgery – an evaluation of: • Health economic costs • Patient-reported outcomes on quality of life • Local bone and soft tissue concentrations • Effect on the gut microbiome A randomised controlled study of dalbavancin versus standard antibiotic treatment of Gram-positive periprosthetic joint infections.
RecruitingCTIS2025-522088-13-00
Region MidtjyllandPeriprosthetic joint infection
Start: 2025-12-12Target: 50Updated: 2025-12-05
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.
Not yet recruitingCTIS2024-516232-10-00
Centre Hospitalier Universitaire De NimesSerious infections in critically ill patients treated with antibiotics
Target: 200Updated: 2025-10-17

Unknown Phase

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