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Calquence 100 mg hard capsules

DRUG20 trials

Sponsors

University Of Saarland, Astrazeneca AB, Kite Pharma Inc., University Of Cologne, Ascentage Pharma Group Inc.

Conditions

Chronic Lymphocytic LeukemiaChronic Lymphocytic Leukemia or Small Lymphocytic LymphomaChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaChronic lymphocytic leukemiaDiffuse large B-cell lymphomaHigh Risk Chronic Lymphocytic LeukaemiaMantle Cell LymphomaMarginal Zone Lymphomas refractory to or in first or greater relapse after prior systemic therapy

Phase 1

Phase 2

A Phase 2 Multicenter Study Evaluating the Efficacy of KTE-X19 in Subjects with Relapsed/Refractory Mantle Cell Lymphoma (ZUMA-2)
CompletedCTIS2023-506641-35-00
Kite Pharma Inc.Relapsed/Refractory Mantle Cell Lymphoma
Start: 2018-07-09End: 2025-06-17Target: 68Updated: 2025-03-10
CLL-Frail - A prospective, multicenter phase II trial of acalabrutinib in very old (≥80y) or frail CLL-Patients
CompletedCTIS2023-507002-14-00
University Of Colognetreatment-naïve or relapsed/refractory chronic lymphocytic leukemia
Start: 2021-05-20End: 2025-05-08Target: 53Updated: 2025-03-10
An Open-label, Phase 2 Study of ACP-196 in Subjects with Mantle Cell Lymphoma
CompletedCTIS2023-509352-34-00
Acerta Pharma B.V.Mantle Cell Lymphoma
Start: 2015-06-18End: 2025-11-03Target: 3Updated: 2025-10-02
Short-term combined acalabrutinib and venetoclax treatment of newly diagnosed patients with CLL at high risk of infection and/or early treatment, who do not fulfil IWCLL treatment criteria for treatment. A randomized study with extensive immune phenotyping.
Not yet recruitingCTIS2024-511072-33-00
RigshospitaletChronic Lymphocytic Leukemia
Target: 50Updated: 2025-03-17
Phase II trial of acalabrutinib in combination with tafasitamab in patients with previously treated marginal zone lymphomas (MZL)
Active, not recruitingCTIS2024-514122-23-00
Association International Extranodal Lymphoma Study Group (IELSG)Marginal Zone Lymphomas refractory to or in first or greater relapse after prior systemic therapy
Start: 2021-10-07Target: 22Updated: 2025-12-08
An Open-label, Phase 2 Study of ACP-196 in Subjects with Waldenström Macroglobulinemia
Active, not recruitingCTIS2023-509356-34-00
Acerta Pharma B.V.Waldenström Macroglobulinemia
Start: 2015-09-28Target: 6Updated: 2025-09-25
FILOCLL14 - STAIR : "Open-label, phase 2 study investigating the STop and restart Acalabrutinib In fRrail patients with previously untreated CLL (STAIR)"
Active, not recruitingCTIS2024-513936-80-00
French Innovative Leukemia Organizationelderly patients (> 70 years) with CLL or SLL
Start: 2021-11-12Target: 160Updated: 2025-12-01

Phase 3

A Randomized, Open-label, Phase 3 Study of Acalabrutinib in Combination with Rituximab and Reduced Dose CHOP (R-miniCHOP) in Older Adults with Untreated Diffuse Large B-Cell Lymphoma (ARCHED/GLA 2022-1)
RecruitingCTIS2022-501187-18-00
University Of Saarlanda. Diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), b. Primary cutaneous DLBCL leg type, c. Intravascular large B-cell lymphoma +13
Start: 2023-04-24Target: 360Updated: 2025-11-04
A Phase III Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib plus Venetoclax versus Venetoclax plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Active, not recruitingCTIS2023-505866-27-00
Astrazeneca ABChronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Start: 2022-10-28Target: 387Updated: 2025-10-21
AVO-CLL: a phase III multicenter, randomized, open-label, clinical trial comparing efficacy and safety of acalabrutinib in combination with obinutuzumab versus venetoclax in combination with obinutuzumab in the first-line treatment of newly diagnosed patients with chronic lymphocytic leukemia
RecruitingCTIS2023-508423-13-00
Specjalistyczny Szpital Im. Dra Alfreda SokolowskiegoChronic lymphocytic leukemia
Start: 2024-07-01Target: 72Updated: 2025-07-18
A Global Multicenter, Open Label, Randomized Phase 3 Registrational Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA Study)
RecruitingCTIS2023-508005-24-00
Ascentage Pharma Group Inc.Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Start: 2024-08-01Target: 232Updated: 2025-12-03
A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects with High Risk Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509347-27-00
Acerta Pharma B.V.High Risk Chronic Lymphocytic Leukaemia
Start: 2015-09-30Target: 17Updated: 2025-09-30
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects ≤75 Years with Previously Untreated Non-Germinal Center Diffuse Large B-Cell Lymphoma
Active, not recruitingCTIS2023-509358-72-00
Acerta Pharma B.V.Diffuse large B-cell lymphoma
Start: 2020-11-23Target: 221Updated: 2025-12-15
A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in Subjects with Chronic Lymphocytic Leukemia
CompletedCTIS2023-507669-24-00
Astrazeneca ABChronic lymphocytic leukemia
Start: 2019-11-05End: 2025-11-04Target: 178Updated: 2025-07-16
A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) in Subjects with Previously Untreated Mantle Cell Lymphoma
Active, not recruitingCTIS2023-509354-58-00
Acerta Pharma B.V.Mantle Cell Lymphoma
Start: 2017-07-14Target: 198Updated: 2025-07-29
A Randomized, Multicenter, Open-Label, 3 Arm Phase 3 Study of Obinutuzumab in Combination with Chlorambucil, ACP 196 in Combination with Obinutuzumab, and ACP-196 Monotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509348-84-00
Acerta Pharma B.V.Chronic Lymphocytic Leukemia
Start: 2015-04-27Target: 212Updated: 2025-12-22
A Randomized, Multicenter, Open-Label, Phase 3 Study of Acalabrutinib (ACP-196) Versus Investigator’s Choice of Either Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Subjects with Relapsed or Refractory Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509359-15-00
Acerta Pharma B.V.Relapsed or Refractory Chronic Lymphocytic Leukemia
Start: 2017-03-08Target: 25Updated: 2025-05-26

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