Calquence 100 mg hard capsules
Sponsors
University Of Saarland, Astrazeneca AB, Kite Pharma Inc., University Of Cologne, Ascentage Pharma Group Inc.
Conditions
Chronic Lymphocytic LeukemiaChronic Lymphocytic Leukemia or Small Lymphocytic LymphomaChronic Lymphocytic Leukemia/Small Lymphocytic LymphomaChronic lymphocytic leukemiaDiffuse large B-cell lymphomaHigh Risk Chronic Lymphocytic LeukaemiaMantle Cell LymphomaMarginal Zone Lymphomas refractory to or in first or greater relapse after prior systemic therapy
Phase 1
A Phase Ib/II Study of APG-2575 as a Single Agent or in Combination with Other Therapeutic Agents in Patients with Relapsed and/or Refractory Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) (SACRED).
RecruitingCTIS2024-515654-25-00
Start: 2021-12-20Target: 60Updated: 2025-09-08
A Phase 1/2, Multicenter, Open-label, and Dose-escalation Study of ACP-196 in Subjects with Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia
Active, not recruitingCTIS2023-509346-35-00
Start: 2015-05-26Target: 1Updated: 2025-12-15
An Open-label, Phase 1b/2 Study of Acalabrutinib Alone or in Combination Therapy in Subjects with B-cell Non-Hodgkin Lymphoma
Active, not recruitingCTIS2023-509350-63-00
Start: 2020-09-16Target: 2Updated: 2025-09-17
Phase 2
A Phase 2 Multicenter Study Evaluating the Efficacy of KTE-X19 in Subjects with Relapsed/Refractory Mantle Cell Lymphoma (ZUMA-2)
CompletedCTIS2023-506641-35-00
Start: 2018-07-09End: 2025-06-17Target: 68Updated: 2025-03-10
CLL-Frail - A prospective, multicenter phase II trial of acalabrutinib in very old (≥80y) or frail CLL-Patients
CompletedCTIS2023-507002-14-00
Start: 2021-05-20End: 2025-05-08Target: 53Updated: 2025-03-10
An Open-label, Phase 2 Study of ACP-196 in Subjects with Mantle Cell Lymphoma
CompletedCTIS2023-509352-34-00
Start: 2015-06-18End: 2025-11-03Target: 3Updated: 2025-10-02
Short-term combined acalabrutinib and venetoclax treatment of newly diagnosed patients with CLL at high risk of infection and/or early treatment, who do not fulfil IWCLL treatment criteria for treatment. A randomized study with extensive immune phenotyping.
Not yet recruitingCTIS2024-511072-33-00
Target: 50Updated: 2025-03-17
Phase II trial of acalabrutinib in combination with tafasitamab in patients with previously treated marginal zone lymphomas (MZL)
Active, not recruitingCTIS2024-514122-23-00
Start: 2021-10-07Target: 22Updated: 2025-12-08
An Open-label, Phase 2 Study of ACP-196 in Subjects with Waldenström Macroglobulinemia
Active, not recruitingCTIS2023-509356-34-00
Start: 2015-09-28Target: 6Updated: 2025-09-25
FILOCLL14 - STAIR : "Open-label, phase 2 study investigating the STop and restart Acalabrutinib In fRrail patients with previously untreated CLL (STAIR)"
Active, not recruitingCTIS2024-513936-80-00
Start: 2021-11-12Target: 160Updated: 2025-12-01
Phase 3
A Randomized, Open-label, Phase 3 Study of Acalabrutinib in Combination with Rituximab and Reduced Dose CHOP (R-miniCHOP) in Older Adults with Untreated Diffuse Large B-Cell Lymphoma (ARCHED/GLA 2022-1)
RecruitingCTIS2022-501187-18-00
Start: 2023-04-24Target: 360Updated: 2025-11-04
A Phase III Prospective, Multicenter, Randomized, Open-Label Trial of Acalabrutinib plus Venetoclax versus Venetoclax plus Obinutuzumab in Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Active, not recruitingCTIS2023-505866-27-00
Start: 2022-10-28Target: 387Updated: 2025-10-21
AVO-CLL: a phase III multicenter, randomized, open-label, clinical trial comparing efficacy and safety of acalabrutinib in combination with obinutuzumab versus venetoclax in combination with obinutuzumab in the first-line treatment of newly diagnosed patients with chronic lymphocytic leukemia
RecruitingCTIS2023-508423-13-00
Start: 2024-07-01Target: 72Updated: 2025-07-18
A Global Multicenter, Open Label, Randomized Phase 3 Registrational Study of Lisaftoclax (APG-2575) in Previously Treated Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (GLORA Study)
RecruitingCTIS2023-508005-24-00
Start: 2024-08-01Target: 232Updated: 2025-12-03
A Randomized, Multicenter, Open-Label, Non-Inferiority, Phase 3 Study of ACP-196 Versus Ibrutinib in Previously Treated Subjects with High Risk Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509347-27-00
Start: 2015-09-30Target: 17Updated: 2025-09-30
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Acalabrutinib in Combination with Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Subjects ≤75 Years with Previously Untreated Non-Germinal Center Diffuse Large B-Cell Lymphoma
Active, not recruitingCTIS2023-509358-72-00
Start: 2020-11-23Target: 221Updated: 2025-12-15
A Phase 3b, Multicenter, Open-Label, Single-Arm Study of Acalabrutinib (ACP-196) in Subjects with Chronic Lymphocytic Leukemia
CompletedCTIS2023-507669-24-00
Start: 2019-11-05End: 2025-11-04Target: 178Updated: 2025-07-16
A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Bendamustine and Rituximab (BR) Alone Versus in Combination with Acalabrutinib (ACP-196) in Subjects with Previously Untreated Mantle Cell Lymphoma
Active, not recruitingCTIS2023-509354-58-00
Start: 2017-07-14Target: 198Updated: 2025-07-29
A Randomized, Multicenter, Open-Label, 3 Arm Phase 3 Study of Obinutuzumab in Combination with Chlorambucil, ACP 196 in Combination with Obinutuzumab, and ACP-196 Monotherapy in Subjects with Previously Untreated Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509348-84-00
Start: 2015-04-27Target: 212Updated: 2025-12-22
A Randomized, Multicenter, Open-Label, Phase 3 Study of Acalabrutinib (ACP-196) Versus Investigator’s Choice of Either Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Subjects with Relapsed or Refractory Chronic Lymphocytic Leukemia
Active, not recruitingCTIS2023-509359-15-00
Start: 2017-03-08Target: 25Updated: 2025-05-26