Host Dysregulation-Driven Sepsis Prediction Model

Construction and Validation of a Sepsis Prediction Model Based on Dysregulation of Host Response

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06523075

Enrollment

1000

Registered

2024-07-26

Start date

2024-09-01

Completion date

2024-10-17

Last updated

2024-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Brief summary

The aim of this study is to identify risk factors associated with sepsis and to construct a predictive model for sepsis. This will provide an objective theoretical and empirical foundation for the diagnosis, assessment, and management of sepsis in our country.The primary questions addressed are: What are the risk factors for the development of sepsis? How do we improve the prognosis of sepsis?

Interventions

OTHERTumor Necrosis Factor

This study is a retrospective observational study, with Tumor Necrosis Factor being one of the exposure factors under investigation.

OTHERInterleukin-1β

This study is a retrospective observational study, with Interleukin-1β being one of the exposure factors under investigation.

OTHERInterleukin-12

This study is a retrospective observational study, with Interleukin-12 being one of the exposure factors under investigation.

OTHERInterleukin-18

This study is a retrospective observational study, with Interleukin-18 being one of the exposure factors under investigation.

OTHERComplement C3

This study is a retrospective observational study, with Complement C3 being one of the exposure factors under investigation.

OTHERComplement C5

This study is a retrospective observational study, with Complement C5 being one of the exposure factors under investigation.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Patients with Infection or Suspected Infection

Exclusion criteria

* Patients with Autoimmune Diseases * Pregnant Women * Patients with Advanced-Stage Cancer and Systemic Metastasis

Design outcomes

Primary

Measure	Time frame	Description
Sepsis	3 months	A rapid increase of 2 or more points points in the Sequential Organ Failure Assessment (SOFA) score after patient infection.SOFA score, which ranges from a minimum of 2 to a maximum of 15, indicates a worse outcome with higher scores.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026