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Tumor Necrosis Factor

DRUG5 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), National Cancer Institute (NCI), University of California, San Francisco, National Institutes of Health Clinical Center (CC), Second Affiliated Hospital of Wenzhou Medical University

Conditions

HIV InfectionsMelanomaRecurrent Adult Soft Tissue SarcomaSarcoma, KaposiSepsisStage IIB Adult Soft Tissue SarcomaStage IIC Adult Soft Tissue SarcomaStage III Adult Soft Tissue Sarcoma

Phase 1

A Phase I/II Study of Intralesional Recombinant Tumor Necrosis Factor in Patients With AIDS-Related Cutaneous Kaposi's Sarcoma
CompletedNCT00002262
University of California, San FranciscoHIV Infections, Sarcoma, Kaposi
Updated: 2005-06-24

Phase 2

A Study of Tumor Necrosis Factor and Human Interferon-gamma in Patients With AIDS Related Complex
CompletedNCT00001004
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
End: 1990-02-28Target: 30Updated: 2021-11-04
Isolated Limb Perfusion of Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Soft Tissue Sarcoma of the Arm or Leg
CompletedNCT00019968
National Institutes of Health Clinical Center (CC)Recurrent Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma, Stage IIC Adult Soft Tissue Sarcoma +3
Start: 1999-08-31End: 2002-03-31Updated: 2023-10-31

Phase 3

A Randomized Phase III Trial of Hyperthermic Isolated Limb Perfusion With Melphalan, Tumor Necrosis Factor, and Interferon-Gamma in Patients With Locally Advanced Extremity Melanoma
CompletedNCT00001296
National Cancer Institute (NCI)Melanoma
Start: 1992-02-29End: 2000-10-31Target: 122Updated: 2008-03-04

Unknown Phase

Host Dysregulation-Driven Sepsis Prediction Model
CompletedNCT06523075
Second Affiliated Hospital of Wenzhou Medical UniversitySepsis
Start: 2024-09-01End: 2024-10-17Updated: 2024-10-31