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Interleukin-12

DRUG10 trials

Sponsors

National Institute of Allergy and Infectious Diseases (NIAID), National Cancer Institute (NCI), Beth Israel Deaconess Medical Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Second Affiliated Hospital of Wenzhou Medical University

Conditions

Acquired Immunodeficiency SyndromeAtypical Mycobacterium InfectionBreast CancerCryptosporidiosisEpidemic Kaposi's SarcomaGlioblastomaGliomaHIV Infections

Phase 1

Interleukin-12 in the Treatment of Severe Nontuberculous Mycobacterial Infections
CompletedNCT00001911
National Institute of Allergy and Infectious Diseases (NIAID)Atypical Mycobacterium Infection
Start: 1999-07-31End: 2003-07-31Target: 10Updated: 2008-03-04
Safety of the Candidate Vaccine C4-V3 Alone or With Interleukin-12 (IL-12) in HIV-Infected Patients Receiving Effective Anti-HIV Drug Therapy
CompletedNCT00005779
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
End: 2004-05-31Target: 12Updated: 2021-11-01
A Study to Evaluate the Effects of Interleukin-12 (rhIL-12) in HIV-Positive Patients With CD4 Cell Counts Less Than 50 Cells/mm3 or 300-500 Cells/mm3
CompletedNCT00000857
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
End: 2001-06-30Target: 65Updated: 2021-10-29
Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection
CompletedNCT00001763
National Institute of Allergy and Infectious Diseases (NIAID)Acquired Immunodeficiency Syndrome, Mycobacterium Avium-Intracellulare Infection
Start: 1998-04-30End: 2000-03-31Target: 15Updated: 2008-03-04
Interleukin-12 in Treating Patients With AIDS-Related Kaposi's Sarcoma
CompletedNCT00019188
National Cancer Institute (NCI)Epidemic Kaposi's Sarcoma, Recurrent Kaposi's Sarcoma
Start: 1997-01-31End: 2007-03-31Updated: 2024-03-04
Vaccination of Patients With Breast Cancer With Dendritic Cell/Tumor Fusions and IL-12
TerminatedNCT00622401
Beth Israel Deaconess Medical CenterBreast Cancer
Start: 2009-12-31End: 2014-10-31Updated: 2017-11-14
Clinical Study of an Dendritic and Glioma Cells Fusion Vaccine With IL-12 for Treatment-naïve GBM Patients.
NCT04388033
Second Affiliated Hospital, School of Medicine, Zhejiang UniversityGlioblastoma, Glioma, Immunologic Factors +5
Start: 2020-12-31End: 2023-12-31Target: 10Updated: 2020-06-09

Unknown Phase

Treatment of Chronic Cryptosporidiosis in AIDS Patients
TerminatedNCT00001128
National Institute of Allergy and Infectious Diseases (NIAID)Cryptosporidiosis, HIV Infections
End: 2005-06-30Target: 16Updated: 2016-12-14
A Study to Compare the Effectiveness of a Four Drug Anti-HIV Regimen Given Alone or in Combination With GM-CSF or IL-12 to HIV-Positive Patients
CompletedNCT00000896
National Institute of Allergy and Infectious Diseases (NIAID)HIV Infections
End: 2000-10-31Target: 24Updated: 2021-10-29
Host Dysregulation-Driven Sepsis Prediction Model
CompletedNCT06523075
Second Affiliated Hospital of Wenzhou Medical UniversitySepsis
Start: 2024-09-01End: 2024-10-17Updated: 2024-10-31