Dietary Lipids as Primary Modulators of Carotenoid Absorption in Vegetables

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01006174

Enrollment

Registered

2009-11-02

Start date

2009-03-31

Completion date

2010-05-31

Last updated

2013-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Absorption of Carotenoids From Vegetables

Brief summary

The purpose of this research study is to determine how dietary fats and oils influence the absorption of beneficial plant pigments (carotenoids) from vegetables. The study will examine changes in blood carotenoids in response to eating a salad with different fats/oils.

Interventions

OTHERSoybean Oil

Depending on the experimental group assigned, each subject which will be given one of three different amounts of soybean oil that is added to a salad.

OTHERCanola Oil

Depending on the experimental group assigned, each subject which will be given one of three different amounts of canola oil that is added to a salad.

OTHERButter

Depending on the experimental group assigned, each subject which will be given one of three different amounts of butter that is added to a salad.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Age range: 18-50 years. * Body mass index (BMI: weight (kg)/height (m2)) ranging from 20-29 kg/m² * Weight stable (\<4.5 kg change within the last 3 months), * Constant habitual activity pattern, not to exceed activities of a recreational level over the past 3 months. * Must be pre-menopausal * Have clinically normal blood profiles (specifically normal liver and kidney functions and fasting blood glucose of ≤110 mg/dl) * Non-smoking * Non-diabetic * No current or planned pregnancy * Not using any hormone-based contraceptive, e.g., pill, patch, injection, implants, etc. * No current use of medication affecting lipid profile * No intestinal disorders including lipid malabsorption, lactose intolerance * No heavy consumption of alcohol (\>2 drinks per day) * No current use of dietary supplements that affect cholesterol, (e.g. Benocol or fiber supplements) or a willingness to discontinue their use during the study.

Exclusion criteria

* Menopausal * Diabetic * Currently pregnant * Currently using any type of hormone-based contraceptives, (e.g., pill, patch, injection, implants, etc.) * Use of lipid altering medications

Design outcomes

Primary

Measure	Time frame
Evaluating the impact of dietary lipid profiles on intestinal absorption of carotenoids from vegetables.	66 days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026