Treatment and prevention of post operative infections
Conditions
Brief summary
T>MIC for all investigated antibiotics in the measured tissues and in plasma, calculated based on concentration–time profiles obtained from microdialysate samples and serial blood sampling. T>MIC will be calculated using predefined MIC target values for each IMP in the primary analysis: cefuroxime 4 mg/L, cloxacillin 2 mg/L, dicloxacillin 2 mg/L, and amoxicillin/clavulanic acid 2 mg/L, expressed as the amoxicillin component.
Detailed description
Pharmacokinetic parameters (Cmax, AUC, Tmax and T½) in tissue and plasma, Concentrations of glucose, lactate, pyruvate and glycerol, as well as inflammatory proteins, in microdialysate samples
Interventions
Sponsors
Region Midtjylland
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T>MIC for all investigated antibiotics in the measured tissues and in plasma, calculated based on concentration–time profiles obtained from microdialysate samples and serial blood sampling. T>MIC will be calculated using predefined MIC target values for each IMP in the primary analysis: cefuroxime 4 mg/L, cloxacillin 2 mg/L, dicloxacillin 2 mg/L, and amoxicillin/clavulanic acid 2 mg/L, expressed as the amoxicillin component. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters (Cmax, AUC, Tmax and T½) in tissue and plasma, Concentrations of glucose, lactate, pyruvate and glycerol, as well as inflammatory proteins, in microdialysate samples | — |
Outcome results
None listed