Opioid-Free Analgesia In Intensive Care Unit : A Prospective, Monocentric, Randomized, Double-Blind, Feasibility Clinical Trial

Conditions

Intubation

Brief summary

daily consumption of remifentanil between the 24th hour and the 48th hour after randomisation of patients admitted to the ICU and requiring at least 72 hours of mechanical ventilation

Detailed description

Cumulative dose of remifentanil, Number of lived days free of remifentanil, Daily consumption of sedative drugs from inclusion to D28, Number of live days free of mechanical ventilation, SOFA Score (Sepsis-related Organ Failure Assessment), Daily fuid intake in milliliter, CAM ICU test, Presence of one or more events of special interest or expected adverse events: constipation, bradycardia, bladder globe, nausea, vomiting, liver disturbance, serotonin syndrome, Presence of pneumonia associated with mechanical ventilation, Extubation failure and cause (reintubation within 48 hours of first extubation), Length of stay in the intensive care unit and in the hospital, Vital status at day 28 and day 90, Opioid use at D90

Related papers

No related papers found yet.

Papers published before 2008-02-04 may not appear yet. Historical indexing is in progress.

Interventions

DRUGNEFOPAM VIATRIS 20 mg/2 ml

DRUGsolution injectable

DRUGTRAMADOL ARROW 100 mg/2 mL

DRUGsolution injectable/pour perfusion

DRUGPARACETAMOL B BRAUN 10 mg/ml

DRUGsolution pour perfusion

DRUGCHLORURE DE SODIUM 0

DRUG9 % AGUETTANT

DRUGULTIVA 5 mg

DRUGpoudre pour solution injectable ou pour perfusion

DRUGKETAMINE RENAUDIN 50 mg/ml

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Design outcomes

Primary

Measure	Time frame
daily consumption of remifentanil between the 24th hour and the 48th hour after randomisation of patients admitted to the ICU and requiring at least 72 hours of mechanical ventilation	—

Secondary

Measure	Time frame
Cumulative dose of remifentanil, Number of lived days free of remifentanil, Daily consumption of sedative drugs from inclusion to D28, Number of live days free of mechanical ventilation, SOFA Score (Sepsis-related Organ Failure Assessment), Daily fuid intake in milliliter, CAM ICU test, Presence of one or more events of special interest or expected adverse events: constipation, bradycardia, bladder globe, nausea, vomiting, liver disturbance, serotonin syndrome, Presence of pneumonia associated with mechanical ventilation, Extubation failure and cause (reintubation within 48 hours of first extubation), Length of stay in the intensive care unit and in the hospital, Vital status at day 28 and day 90, Opioid use at D90	—

Measure

Time frame

Cumulative dose of remifentanil, Number of lived days free of remifentanil, Daily consumption of sedative drugs from inclusion to D28, Number of live days free of mechanical ventilation, SOFA Score (Sepsis-related Organ Failure Assessment), Daily fuid intake in milliliter, CAM ICU test, Presence of one or more events of special interest or expected adverse events: constipation, bradycardia, bladder globe, nausea, vomiting, liver disturbance, serotonin syndrome, Presence of pneumonia associated with mechanical ventilation, Extubation failure and cause (reintubation within 48 hours of first extubation), Length of stay in the intensive care unit and in the hospital, Vital status at day 28 and day 90, Opioid use at D90

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Countries

France

Outcome results

None listed