KETAMINE RENAUDIN 50 mg/ml

DRUG4 trials

Sponsors

Centre Hospitalier Universitaire De Nimes, Centre Hospitalier Universitaire De Nice, University Hospital Of Clermont-Ferrand, Assistance Publique Hopitaux De Paris

Conditions

Adult patients admitted to the ICU and receiving unplanned invasive mechanical ventilationIntubationSevere acute painrefractory chronic cluster headache

Phase 2

KARMA - INtenSive care TreAtmeNT with adjuvant KetAmine and Recovery after Mechanical ventilAtion: a multicenter doubleblind randomized controlled trial

Not yet recruitingCTIS2025-523149-80-00

Assistance Publique Hopitaux De ParisAdult patients admitted to the ICU and receiving unplanned invasive mechanical ventilation

Target: 640Updated: 2026-04-20

Phase 3

KETALGIA : Evaluation of the effectiveness of a ketamine infusion combined with magnesium sulfate in the treatment of chronic refractory cluster headache

Active, not recruitingCTIS2024-518943-38-00

University Hospital Of Clermont-Ferrandrefractory chronic cluster headache

Start: 2021-09-15Target: 90Updated: 2025-12-17

Phase 4

Opioid-Free Analgesia In Intensive Care Unit : A Prospective, Monocentric, Randomized, Double-Blind, Feasibility Clinical Trial

Active, not recruitingCTIS2024-517770-14-00

Centre Hospitalier Universitaire De NimesIntubation

Start: 2025-11-24Target: 50Updated: 2025-11-19

Randomized controlled double-blind study ESKAPE : ESKetamine low-dose versus ketamine low-dose for Severe Acute Pain in Emergency Departments, comparison of PsychodyslEptic effects

RecruitingCTIS2024-518733-29-00

Centre Hospitalier Universitaire De NiceSevere acute pain

Start: 2025-04-29Target: 74Updated: 2025-05-27