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Teprotumumab

DRUG13 trials

Sponsors

Horizon Therapeutics USA Inc., Amgen

Conditions

Diabetic Macular EdemaGraves' OrbitopathyHealthy VolunteersModerate-to-Severe Active Thyroid Eye DiseaseThyroid Associated OphthalmopathiesThyroid Eye DiseaseThyroid-Associated Ophthalmopathy

Phase 1

Phase 2

Phase 3

Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study
CompletedNCT03298867
AmgenGraves' Orbitopathy, Thyroid Eye Disease
Start: 2017-10-04End: 2020-11-30Updated: 2024-07-11
Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study
CompletedNCT03461211
AmgenThyroid Eye Disease
Start: 2018-04-16End: 2021-02-17Updated: 2024-06-28
A Trial to Investigate Teprotumumab Subcutaneous Administration Compared With Placebo in Male and Female Adult Participants With Moderate-to-severe Active Thyroid Eye Disease
Active, not recruitingNCT06248619
AmgenThyroid Eye Disease
Start: 2024-07-05End: 2026-11-13Updated: 2026-07-07
A Phase 3b/4, Double-masked, Randomized, International, Parallel-assignment, Multicenter Trial in Patients with Thyroid Eye Disease to Evaluate the Safety and Tolerability of Different Dosing Durations of Teprotumumab
Active, not recruitingCTIS2024-515090-96-00
Horizon Therapeutics USA Inc.Thyroid Eye Disease
Start: 2022-05-10Target: 214Updated: 2026-01-19
A Phase 3, Randomized, Double-masked, Placebo-controlled, Parallel-group, Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of Subcutaneous Teprotumumab in Participants with Moderate-to-Severe Active Thyroid Eye Disease
RecruitingCTIS2024-515702-63-00
Horizon Therapeutics USA Inc.Moderate-to-Severe Active Thyroid Eye Disease
Start: 2025-02-20Target: 31Updated: 2025-12-03

Phase 4

Unknown Phase

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