Stereotactic Radiation Therapy

RADIATION11 trials

Sponsors

Sidney Kimmel Cancer Center at Thomas Jefferson University, Mayo Clinic, Stanford University, University of Louisville, GT Medical Technologies, Inc.

Conditions

Brain MetastasesBrain Metastases from Non-small Cell Lung CancerBreast CancerEarly-Stage Breast CarcinomaGlioblastomaGlioblastoma MultiformeHER2-Negative Breast CancerHormone Receptor-Positive Breast Cancer

Phase 1

Stereotactic Radiation Therapy in Treating Patients With Liver Metastases

TerminatedNCT00938457

Mayo ClinicUnspecified Adult Solid Tumor

Start: 2009-07-31Updated: 2016-05-19

Trial of Anti-PD-1 Immunotherapy and Stereotactic Radiation in Patients With Recurrent Glioblastoma

RecruitingNCT04977375

Chirag G. PatilGlioblastoma Multiforme

Start: 2021-12-09End: 2028-12-01Target: 10Updated: 2026-09-21

Phase 2

Durvalumab and Stereotactic Radiotherapy for Advanced NSCLC

TerminatedNCT04786093

University of Texas Southwestern Medical CenterNon Small Cell Lung Cancer

Start: 2021-07-27End: 2022-06-09Updated: 2026-05-05

Durvalumab (MEDI4736) and Radiosurgery (fSRT Vs. PULSAR) for the Treatment of Non-Small Cell Lung Cancer Brain Metastases

WithdrawnNCT04889066

University of Texas Southwestern Medical CenterBrain Metastases from Non-small Cell Lung Cancer

Start: 2024-10-01End: 2025-01-31Updated: 2024-12-20

SRT Combined With Envafolimab and Endostar in the First-line Treatment of Advanced NSCLC

Not yet recruitingNCT07818304

The First People's Hospital of LianyungangLung Neoplasms, Non Small Cell Lung Cancer

Start: 2026-10-01End: 2028-10-01Target: 61Updated: 2026-09-14

Phase 3

Comparing Two Forms of Head Immobilization for Stereotactic Radiotherapy

CompletedNCT00328510

Sidney Kimmel Cancer Center at Thomas Jefferson Universityfor Brain Tumors, Patients Receiving Fractionated Stereotactic Radiotherapy

Start: 2005-02-28End: 2009-09-30Updated: 2016-11-29

Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study)

Active, not recruitingNCT04365374

GT Medical Technologies, Inc.Brain Metastases

Start: 2021-04-06End: 2029-08-30Target: 230Updated: 2025-10-07

Phase 4

Post-operative Adjuvant Therapy w/wo GammaTile + Systemic Therapy

WithdrawnNCT05900908

GT Medical Technologies, Inc.Glioblastoma

Start: 2025-05-31End: 2028-06-30Updated: 2025-04-10

Unknown Phase

Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy

CompletedNCT01129687

Stanford UniversityNeuroma, Acoustic

Start: 2005-03-31End: 2022-05-08Updated: 2022-05-10

Phase II Trial of Stereotactic Radiation Therapy (SRT) Versus SRT Plus Vertebral Augmentation Procedure (VAP) for Vertebral Metastasis

TerminatedNCT01527292

University of LouisvilleVertebral Metastasis

Start: 2012-02-29End: 2015-09-02Updated: 2019-02-05

SOLIS: Single-Dose Radiotherapy With Omission of Lumpectomy for Intact Small Breast Cancers

Not yet recruitingNCT07844759

Renaissance Institute of Precision Oncology and RadiosurgeryBreast Cancer, Early-Stage Breast Carcinoma, HER2-Negative Breast Cancer +1

Start: 2027-01-01End: 2032-01-01Target: 30Updated: 2026-09-28

Related Papers

Surgery and tile-based radiation therapy versus surgery and stereotactic radiation for newly diagnosed brain metastases (ROADS): a randomized, open-label, phase 3 trial

Journal of Clinical Oncology2026-09-28

Final results of a randomized, controlled, phase 3 trial comparing resection and post-operative stereotactic radiation versus resection and cesium-131 tile-based radiation for treatment of newly diagnosed brain metastases.

Journal of Clinical Oncology2026-06-03

Early Experience and Perioperative Risk of GammaTile® for Upfront Brain Metastases: Report from a Prospective Multicenter Study

Neuro-Oncology Advances2024-09-10

A phase 3 randomized controlled trial of post-surgical stereotactic radiotherapy versus surgically targeted radiation therapy with GammaTile for treatment of newly diagnosed metastatic brain tumors.

Journal of Clinical Oncology2024-06-01

Dosimetric Impacts of Source Migration, Radioisotope Type, and Decay with Permanent Implantable Collagen Tile Brachytherapy for Brain Tumors

Technology in Cancer Research & Treatment2022-01-0111 citations

Beyond Fractionation

Oncology Times2021-12-162 citations

Clinical Trials in Progress: ROADS Trial

ONCOLOGY2021-08-014 citations

A phase III multicenter randomized controlled trial of postsurgical stereotactic radiotherapy versus surgically targeted radiation therapy (STaRT) for the treatment of large (>2.5cm) newly diagnosed brain metastases: Trial in progress.

Journal of Clinical Oncology2021-05-20