Standard oxygen

DEVICE12 trials

Sponsors

The Cleveland Clinic, Tufts Medical Center, Assistance Publique - Hôpitaux de Paris, Poitiers University Hospital, University Hospital, Brest

Conditions

Acute Hypoxemic Respiratory FailureAcute Lung InjuryAcute Respiratory Distress SyndromeAcute Respiratory FailureAcute Respiratory Failure With HypoxiaAcute Viral BronchitisAcute on Chronic Respiratory FailureCOPD Exacerbation

Phase 4

Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease

RecruitingNCT05703919

Central Denmark RegionCOPD Exacerbation, COPD Exacerbation Acute

Start: 2025-06-02End: 2028-05-31Target: 1888Updated: 2025-06-10

Unknown Phase

Supplemental Oxygen Reduces Surgical Infection

CompletedNCT00235456

The Cleveland ClinicWound Infection

Start: 2003-03-31End: 2005-01-31Updated: 2017-02-10

Treatment of Dyspnea in Do-not-intubate Patients

TerminatedNCT02114944

Tufts Medical CenterAcute on Chronic Respiratory Failure, Acute Respiratory Failure, Dyspnea

Start: 2014-04-30End: 2023-12-01Target: 400Updated: 2025-05-13

A Randomised Controlled Trial of High-Flow Nasal Oxygen Versus Standard Oxygen Therapy in Critically Ill Immunocompromised Patients

CompletedNCT02739451

Assistance Publique - Hôpitaux de ParisAcute Respiratory Failure

Start: 2016-05-31End: 2017-12-31Updated: 2018-07-24

Early Initiation of High-flow Nasal Cannula Oxygen Therapy in Patients With Acute Respiratory Failure in the Emergency Department: A Before-after Study

CompletedNCT03447457

Poitiers University HospitalAcute Respiratory Failure

Start: 2015-12-01End: 2017-05-30Updated: 2018-02-27

Management of Moderately Hypoxemic Thoracic Trauma

Active, not recruitingNCT03997630

University Hospital, BrestChest Trauma, High Flow Oxygenation

Start: 2019-11-12End: 2026-02-28Target: 770Updated: 2025-05-14

Standard Oxygen Versus High Flow Nasal Cannula Oxygen Therapy in Patients With Acute Hypoxemic Respiratory Failure

CompletedNCT04468126

Poitiers University HospitalAcute Respiratory Failure, Hypoxemic Respiratory Failure

Start: 2021-01-19End: 2024-12-31Updated: 2026-01-22

The Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) Study

CompletedNCT04693403

Makerere UniversityAcute Lung Injury, Acute Respiratory Distress Syndrome, Acute Respiratory Failure With Hypoxia

Start: 2023-03-13End: 2024-03-31Updated: 2025-08-14

NHF vs. COT in Hypoxemic Pandemic Viral Illness

Jens BräunlichAcute Viral Bronchitis, Hypercapnic Respiratory Failure, Hypoxemic Respiratory Failure

Start: 2021-01-22End: 2022-06-22Target: 52Updated: 2022-03-31

Comparing High-flow Nasal Cannula Oxygen and Noninvasive Ventilation to Standard Oxygenation in Non-selected ICU Patients Admitted for Hypoxemic ARF

RecruitingNCT05812911

University Hospital, MontpellierAcute Respiratory Failure

Start: 2023-05-23End: 2026-08-23Target: 2100Updated: 2025-05-07

High Flow Nasal Oxygen for Acute Hypoxemic Respiratory Failure in the Emergency Room

Not yet recruitingNCT06489379

Fondazione Policlinico Universitario Agostino Gemelli IRCCSRespiratory Distress Syndrome, Adult

Start: 2024-07-31End: 2026-07-31Target: 234Updated: 2024-07-05

Bag CPAP vs Standard Oxygen Therapy in Acute Hypoxemic Respiratory Failure

Not yet recruitingNCT07460427

Prof RWABIHAMA Jean PaulAcute Hypoxemic Respiratory Failure

Start: 2026-04-20End: 2027-03-20Target: 250Updated: 2026-03-19

Related Papers

High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure.

2026-03-17

Comparing high-flow nasal cannula oxygen and non-invasive ventilation to standard oxygenation in non-selected intensive care unit patients admitted for acute hypoxaemic respiratory failure: protocol for the KISS (Key oxygenation Interventions in Surgical and non-Surgical patients) adaptive randomised controlled trial.

2025-10-20

Effect of high-flow nasal cannula oxygen versus standard oxygen on mortality in patients with acute hypoxaemic respiratory failure: protocol for a multicentre, randomised controlled trial (SOHO)

BMJ Open2024-10-011 citations

Respiratory support with standard low-flow oxygen therapy, high-flow oxygen therapy or continuous positive airway pressure in adults with acute hypoxaemic respiratory failure in a resource-limited setting: protocol for a randomised, open-label, clinical trial – the Acute Respiratory Intervention StudiEs in Africa (ARISE-AFRICA) study

BMJ Open2024-06-015 citations

Standard vs. targeted oxygen therapy prehospitally for chronic obstructive pulmonary disease (STOP-COPD): study protocol for a randomised controlled trial.

2024-01-259 citations

Effect of High-Flow Nasal Cannula Oxygen vs Standard Oxygen Therapy on Mortality in Patients With Respiratory Failure Due to COVID-19

JAMA2022-09-27115 citations

Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure

JAMA2018-10-25289 citations

High-flow nasal oxygen vs. standard oxygen therapy in immunocompromised patients with acute respiratory failure: study protocol for a randomized controlled trial.

2018-03-059 citations