Acute Viral Bronchitis, Hypoxemic Respiratory Failure, Hypercapnic Respiratory Failure
Conditions
Brief summary
The study compares oxygen and NHF in patients with acute viral illness. The duration will be 72h. After them physiological parameters and the outcome will be evaluated.
Interventions
DEVICEStandard oxygen
COT describes the application of low-flow oxygen in any way (Hudson mask, nasal prongs,...).
DEVICENasal high-flow
F is combination of room air supplemented with oxygen can be better patients. This gas mixture will be provided to the patient with a specialized nasal prong.
Sponsors
Jens Bräunlich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* acute hyperemic viral illness * acute hyperemic or hypercapnia respiratory failure
Exclusion criteria
* intubation criteria * indication for NIV therapy * influences of primary endpoint (rip fracture, lung embolism) * tracheostomy * other interventional trials * noncompliance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rox index | 72 hours | (SpO2/FiO2)/RR = index without a unit, mean Rox-index in the two groups, comparison between the groups (significant differences), physiological parameter, to assess differences between the two groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| paCO2 in mmHg | 72 hours | physiological parameter, to assess differences between the two groups |
| pH | 72 hours | physiological parameter, to assess differences between the two groups |
| escalation of therapy | 72 hours | use of noninvasive ventilation, intubation, to assess differences between the two groups |
| paO2 in mmHg | 72 hours | physiological parameter, to assess differences between the two groups |
Countries
Germany
Contacts
Primary ContactJens Bräunlich, MD
Outcome results
None listed