rabbit antithymocyte globulin

DRUG12 trials

Sponsors

European Society for Blood and Marrow Transplantation, University of Pennsylvania, University of Cincinnati, Columbia University, Medical University of South Carolina

Conditions

Acute Lymphoid Leukemia (ALL)Acute Myeloid Leukemia (AML)AnemiaAplastic AnemiaChronic Lymphocytic LeukemiaChronic Myeloid Leukemia (CML)End Stage Renal DiseaseGraft-versus-host Disease

Phase 1

Double Cord Blood Transplant for Patients With Malignant and Non-malignant Disorders

TerminatedNCT00801931

Columbia UniversityAnemia, Immunodeficiencies, Leukemia +2

Start: 2007-09-06End: 2009-05-05Updated: 2019-03-27

Nonmyeloablative Conditioning and Transplantation for Patients With Refractory Systemic Lupus Erythematosus (SLE)

TerminatedNCT02080195

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsGraft-versus-host Disease, Lupus Erythematosus

Start: 2016-09-13End: 2017-03-29Updated: 2019-10-02

Phase 2

Rabbit Antithymocyte Globulin (Thymoglobuline) With Ciclosporin for Patients With Acquired Aplastic Anaemia

CompletedNCT00471848

European Society for Blood and Marrow TransplantationAplastic Anemia

Start: 2008-08-31End: 2013-02-28Updated: 2023-09-26

Preemptive Therapy of GVHD

TerminatedNCT01994824

University of CalgaryGraft-vs-host Disease

Start: 2014-01-31End: 2021-09-27Updated: 2023-11-30

Donor Stem Cell Transplantation Using α/β+ T-lymphocyte Depleted Grafts From HLA Mismatched Donors

TerminatedNCT03615105

Memorial Sloan Kettering Cancer CenterAcute Lymphoid Leukemia (ALL), Acute Myeloid Leukemia (AML), Chronic Lymphocytic Leukemia +3

Start: 2018-07-25End: 2024-03-06Updated: 2025-04-06

A Single-arm Trial of Prophylactic Tocilizumab for Acute GVHD Prevention After Haploidentical HSCT.

Yi LuoGraft-versus-host-disease, Leukemia

Start: 2020-12-03End: 2024-12-31Target: 46Updated: 2023-02-21

Phase 3

A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies

RecruitingNCT04547049

First Affiliated Hospital of Zhejiang UniversityLeukemia

Start: 2020-09-01End: 2025-12-31Target: 176Updated: 2025-03-25

Phase 4

Prednisone Withdrawal Versus Prednisone Maintenance After Kidney Transplant

TerminatedNCT00596947

University of PennsylvaniaTransplants and Implants

Start: 2005-10-31End: 2009-03-31Updated: 2017-05-15

Randomized Trial of Induction Therapies in High Immunological Risk Kidney Transplant Recipients

CompletedNCT00782821

University of CincinnatiKidney Transplantation

Start: 2008-09-30End: 2013-03-31Updated: 2016-01-20

Belatacept Early Steroid Withdrawal Trial

CompletedNCT01729494

University of CincinnatiRenal Transplantation

Start: 2012-09-30End: 2019-12-31Updated: 2021-07-28

Belatacept With Early Steroid Withdrawal rATG and Everolimus in Renal Transplantation (BETTER Trial)

University of CincinnatiKidney Transplant Rejection

Start: 2021-04-09End: 2024-07-31Target: 120Updated: 2021-04-19

Unknown Phase

Safety and Efficacy Study of Thymoglobulin Versus IL2 Receptor Antagonists

CompletedNCT00859131

Medical University of South CarolinaEnd Stage Renal Disease

Start: 2009-03-31End: 2014-07-31Updated: 2016-04-26

Related Papers

Belatacept Pharmacokinetic Analysis of Belatacept Early Steroid Withdrawal Trial (BEST) to Clinical Outcomes and Compared With Reported BENEFIT and BENEFIT-EXT Pharmacokinetic Analysis.

2025-08-01

A biomarker-guided, prospective, phase 2 trial of pre-emptive graft-versus-host disease therapy using anti-thymocyte globulin.

2021-08-065 citations

Belatacept for Simultaneous Calcineurin Inhibitor and Chronic Corticosteroid Immunosuppression Avoidance

Clinical Journal of the American Society of Nephrology2021-07-0731 citations

mTOR Inhibitor Therapy Diminishes Circulating CD8+ CD28− Effector Memory T Cells and Improves Allograft Inflammation in Belatacept-refractory Renal Allograft Rejection

Transplantation2019-08-1421 citations

Prospective Randomized Controlled Trial of Rabbit Antithymocyte Globulin Compared With IL-2 Receptor Antagonist Induction Therapy in Kidney Transplantation

Annals of Surgery2014-02-1145 citations

Prospective study of rabbit antithymocyte globulin and cyclosporine for aplastic anemia from the EBMT Severe Aplastic Anaemia Working Party.

2012-04-27133 citations