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Preoperative radiotherapy

RADIATION16 trials

Sponsors

Hoffmann-La Roche, Karolinska Institutet, Jagiellonian University, Sichuan Cancer Hospital and Research Institute, CNAO National Center of Oncological Hadrontherapy

Conditions

Brain MetastasesBreast AdenocarcinomaBreast CancerBreast CarcinomaBreast NeoplasmsCancerCancer of PancreasEfficacy and Safety

Phase 2

A Study of Bevacizumab (Avastin) in Participants With Newly Diagnosed Locally Advanced Rectal Cancer
CompletedNCT00865189
Hoffmann-La RocheRectal Cancer
Start: 2007-10-23End: 2016-03-23Updated: 2017-08-04
Changes in Tumor Tissue and Serum Biomarkers Before and After Cetuximab Combined With Preoperative Radiotherapy in Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma
NCT02123381
Sichuan Cancer Hospital and Research InstituteLocally Advanced Thoracic Middle-lower Segment Esophageal Squamous Cell Carcinoma
Start: 2014-04-30End: 2020-07-31Target: 100Updated: 2020-03-17
Carbon Ions Radiation Therapy for Resectable or Borderline Resectable Pancreas Adenocarcinoma
TerminatedNCT03822936
CNAO National Center of Oncological HadrontherapyCancer of Pancreas, Pancreas Adenocarcinoma, Resectable Pancreatic Cancer
Start: 2018-02-08End: 2025-02-10Updated: 2025-02-13
Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases
RecruitingNCT05871307
University Hospital HeidelbergBrain Metastases, Radiotherapy
Start: 2024-02-01End: 2028-05-01Target: 90Updated: 2024-05-08
Perioperative Treatment of Combined Radiotherapy With SOX, Apatinib and Camrelizumab for Oesophagogastric Cancer
RecruitingNCT07026149
Ruijin HospitalGastric and Gastroesophageal Junction (GEJ) Adenocarcinoma
Start: 2025-06-08End: 2030-05-31Target: 30Updated: 2025-06-18

Phase 3

NeoRad Breast Cancer Study
RecruitingNCT04261244
Bielefeld UniversityBreast Cancer
Start: 2024-02-01End: 2034-03-31Target: 1826Updated: 2025-05-07
Surgery Plus Chemo Versus Chemoradiotherapy Followed by Surgery Plus Chemo for Locally Recurrent Rectal Cancer
RecruitingNCT04288999
National Cancer Center Hospital EastRectal Cancer Recurrent
Start: 2019-10-01End: 2028-10-31Target: 110Updated: 2020-06-04
PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy Plus Surgery for Locally Advanced ESCC (NEOCRTEC2101)
RecruitingNCT05357846
Sun Yat-sen UniversityEsophageal Cancer, Oesophageal Cancer, Squamous Cell Esophageal Carcinoma
Start: 2022-11-01End: 2031-01-31Target: 422Updated: 2025-06-12

Unknown Phase

Sexual Function and Wellbeing in Males With Rectal Cancer
CompletedNCT01216202
Karolinska InstitutetRectal Cancer
Start: 2010-04-30End: 2016-05-31Updated: 2023-10-04
Sexual Function and Wellbeing in Females With Rectal Cancer
CompletedNCT01216189
Karolinska InstitutetRectal Cancer
Start: 2008-06-30End: 2015-12-31Updated: 2021-04-09
Randomized Clinical Trial on Preoperative Radiotherapy 25 Gy in Rectal Cancer
CompletedNCT01444495
Jagiellonian UniversityRectal Cancer
Start: 1999-01-31End: 2010-12-31Updated: 2023-02-15
Patient-Reported Outcome and Safety Between Preoperative and Postmastectomy Radiotherapy in DIEP Flap Reconstruction
RecruitingNCT05512286
Fudan UniversityBreast Cancer
Start: 2022-08-25End: 2027-10-01Target: 80Updated: 2024-11-25
Preoperative Radiation Therapy and Immediate Breast Reconstruction
RecruitingNCT06739655
Cancer Research AntwerpBreast Adenocarcinoma, Breast Carcinoma, Breast Neoplasms +2
Start: 2025-02-20End: 2038-02-20Target: 180Updated: 2026-02-04
Safety and Efficacy of IMPT or IMRT for Breast Cancer
RecruitingNCT06826885
Ruijin HospitalBreast Cancer, Efficacy and Safety, Intensity Modulated Radiation Therapy +2
Start: 2024-12-01End: 2029-11-30Target: 500Updated: 2025-02-14
Short Course of Radiotherapy Prior to Surgery of Soft Tissue Sarcomas
RecruitingNCT07071727
The Netherlands Cancer InstituteSarcoma, Sarcoma of Soft Tissue, Sarcoma, Soft Tissue
Start: 2025-12-11End: 2033-11-01Target: 150Updated: 2026-02-19
Neoadjuvant Chemotherapy Combined With Preoperative Radiotherapy for Locally Advanced Breast Cancer
Not yet recruitingNCT07164872
Cancer Institute and Hospital, Chinese Academy of Medical SciencesBreast Cancer
Start: 2025-10-01End: 2032-12-31Target: 50Updated: 2025-09-10

Related Papers

Abstract P3-10-22: Preoperative radiotherapy versus postoperative radiotherapy after neoadjuvant chemotherapy in high-risk breast cancer: a prospective, randomized, international multicentre Phase III trial—NeoRad
Clinical Cancer Research2025-06-13
Protocol for a multicentre, prospective, open-label, randomised controlled trial to compare PROs and safety outcomes between preoperative and postmastectomy radiotherapy in locally advanced breast cancer patients with immediate reconstruction via a deep inferior epigastric perforator flap (CAPPELLA) in China
BMJ Open2025-01-011 citations
Preoperative chemo-CIRT in Re/BRe pancreatic cancer: Insights from a multicenter prospective phase II clinical study (NCT03822936)
Tumori Journal2024-10-272 citations
Utility of circulating tumour DNA for prognosis and prediction of therapeutic effect in locally recurrent rectal cancer: study protocol for a multi-institutional, prospective observational study (JCOG1801A1, CAP-LR study)
BMJ Open2023-08-011 citations
Prognostic value of lymph node ratio in resectable rectal cancer after preoperative short-course radiotherapy-results from randomized clinical trial.
2022-07-041 citations
Preoperative radiotherapy 5 × 5 Gy and short versus long interval between surgery for resectable rectal cancer: 10-Year follow-up of the randomised controlled trial.
2021-10-139 citations
Carbon ion radiotherapy as definitive treatment in non-metastasized pancreatic cancer: study protocol of the prospective phase II PACK-study
BMC Cancer2020-10-0119 citations
A phase III randomized controlled trial comparing surgery plus adjuvant chemotherapy with preoperative chemoradiotherapy followed by surgery plus adjuvant chemotherapy for locally recurrent rectal cancer: Japan Clinical Oncology Group study JCOG1801 (RC-SURVIVE study)
Japanese Journal of Clinical Oncology2020-04-138 citations
Preoperative chemotherapy and carbon ions therapy for treatment of resectable and borderline resectable pancreatic adenocarcinoma: a prospective, phase II, multicentre, single-arm study.
2019-09-1426 citations