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Placebo to Methotrexate

DRUG4 trials

Sponsors

Hoffmann-La Roche, AbbVie (prior sponsor, Abbott), Amgen, AbbVie

Conditions

Plaque PsoriasisPsoriatic ArthritisRheumatoid Arthritis

Phase 3

A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis
CompletedNCT01007435
Hoffmann-La RocheRheumatoid Arthritis
Start: 2009-10-31End: 2014-01-28Updated: 2017-07-26
A Double Blind Study in Pediatric Subjects With Chronic Plaque Psoriasis, Studying Adalimumab vs. Methotrexate
CompletedNCT01251614
AbbVie (prior sponsor, Abbott)Plaque Psoriasis
Start: 2010-12-31End: 2015-02-28Updated: 2017-09-25
Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis
CompletedNCT02376790
AmgenPsoriatic Arthritis
Start: 2015-03-03End: 2018-07-06Updated: 2022-09-21
A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken Methotrexate
CompletedNCT02706873
AbbVieRheumatoid Arthritis
Start: 2016-02-23End: 2022-11-10Updated: 2023-07-07

Related Papers

Safety Profile of Upadacitinib: Descriptive Analysis in Over 27,000 Patient-Years Across Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Atopic Dermatitis, and Inflammatory Bowel Disease.
2025-08-282 citations
Upadacitinib monotherapy versus methotrexate monotherapy in patients with rheumatoid arthritis: efficacy and safety through 5 years in the SELECT-EARLY randomized controlled trial
Arthritis Research & Therapy2024-07-2910 citations
Malignancy in the Upadacitinib Clinical Trials for Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis
Rheumatology and Therapy2023-11-2020 citations
MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
RMD Open2023-11-0123 citations
Safety profile of upadacitinib in patients at risk of cardiovascular disease: integrated post hoc analysis of the SELECT phase III rheumatoid arthritis clinical programme.
2023-06-1238 citations
Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis
RMD Open2023-02-01180 citations
Safety of upadacitinib in Latin American patients with rheumatoid arthritis: an integrated safety analysis of the SELECT phase 3 clinical program.
2023-01-303 citations
Routine Assessment of Patient Index Data 3 (RAPID3) in Patients with Rheumatoid Arthritis Treated with Long-Term Upadacitinib Therapy in Five Randomized Controlled Trials
Rheumatology and Therapy2022-09-20
Potential Impact of Sex and BMI on Response to Therapy in Psoriatic Arthritis: Post Hoc Analysis of Results From the SEAM-PsA Trial
The Journal of Rheumatology2022-04-1517 citations
Inhibition of structural joint damage progression with upadacitinib in rheumatoid arthritis: 1-year outcomes from the SELECT phase 3 program
Lara D. Veeken2021-12-0912 citations
The Safety Profile of Upadacitinib in Patients with Rheumatoid Arthritis in Japan.
2021-05-2717 citations
Upadacitinib monotherapy improves patient-reported outcomes in rheumatoid arthritis: results from SELECT-EARLY and SELECT-MONOTHERAPY
Lara D. Veeken2020-11-1619 citations
Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme
Annals of the Rheumatic Diseases2020-10-28219 citations
Performance of composite measures used in a trial of etanercept and methotrexate as monotherapy or in combination in psoriatic arthritis
Lara D. Veeken2020-04-2814 citations
Population Pharmacokinetics of Upadacitinib in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I and II Clinical Trials.
2018-08-0161 citations
Safety of Adalimumab in Pediatric Patients with Polyarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Psoriasis, and Crohn's Disease.
2018-07-2528 citations
Efficacy and safety of adalimumab every other week versus methotrexate once weekly in children and adolescents with severe chronic plaque psoriasis: a randomised, double-blind, phase 3 trial.
2017-05-0487 citations
Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial.
2017-04-0760 citations
Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
Annals of the Rheumatic Diseases2015-10-29193 citations