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Placebo for Upadacitinib

DRUG18 trials

Sponsors

Abbvie Deutschland GmbH & Co. KG, Dr. Douglas D. Fraser, AbbVie, Douglas D. Fraser

Conditions

Atopic DermatitisAtopic Dermatitis (AD)Crohn's DiseaseLong COVIDLong CovidModerate and Severe Atopic DermatitisRheumatoid ArthritisRheumatoid Arthritis (RA)

Phase 2

Phase 3

A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who Are on a Stable Dose of Methotrexate and Who Have an Inadequate Response to Methotrexate
Active, not recruitingNCT02629159
AbbVieRheumatoid Arthritis
Start: 2015-12-01End: 2027-09-30Updated: 2025-08-05
A Phase 3 Study to Compare Upadacitinib to Abatacept in Subjects With Rheumatoid Arthritis on Stable Dose of Conventional Synthetic Disease- Modifying Antirheumatic Drugs (csDMARDs) Who Have an Inadequate Response or Intolerance to Biologic DMARDs
CompletedNCT03086343
AbbVieRheumatoid Arthritis (RA)
Start: 2017-05-09End: 2023-06-06Updated: 2024-07-18
A Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Crohn's Disease Who Completed the Studies M14-431 or M14-433
Active, not recruitingNCT03345823
AbbVieCrohn's Disease
Start: 2018-03-21End: 2027-09-30Target: 747Updated: 2025-08-05
A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies
CompletedNCT03345849
AbbVieCrohn's Disease
Start: 2017-12-07End: 2022-01-13Updated: 2022-11-23
Evaluation of Upadacitinib in Adolescent and Adult Patients With Moderate to Severe Atopic Dermatitis (Eczema)
CompletedNCT03569293
AbbVieAtopic Dermatitis
Start: 2018-08-13End: 2025-10-10Updated: 2025-10-24
A Study to Evaluate Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis (Measure Up 2)
CompletedNCT03607422
AbbVieAtopic Dermatitis
Start: 2018-07-27End: 2025-11-11Updated: 2025-12-03
A Study to Evaluate Safety of Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
CompletedNCT03661138
AbbVieAtopic Dermatitis
Start: 2018-10-27End: 2022-08-19Updated: 2023-03-01
A Study to Evaluate the Efficacy and Safety of Upadacitinib in Participants With Takayasu Arteritis (TAK)
Active, not recruitingNCT04161898
AbbVieTakayasu Arteritis (TAK)
Start: 2020-02-04End: 2028-08-01Target: 56Updated: 2026-02-18
A Study of Oral Upadacitinib Tablets to Assess Change in Disease State in Participants Aged 12-75 Years With Moderate to Severe Atopic Dermatitis in Brazil
WithdrawnNCT04666675
AbbVieAtopic Dermatitis (AD)
Start: 2020-12-24End: 2021-03-23Updated: 2021-04-08
SELECT-SLE: A Phase 3 Program to Evaluate the Safety and Efficacy of Upadacitinib in Subjects with Moderately to Severely Active SLE
RecruitingCTIS2023-503655-10-00
Abbvie Deutschland GmbH & Co. KGSystemic Lupus Erythematosus (SLE).
Start: 2023-11-20Target: 271Updated: 2025-12-16
A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Subjects with Moderate to Severe Atopic Dermatitis
CompletedCTIS2022-502936-38-00
Abbvie Deutschland GmbH & Co. KGModerate and Severe Atopic Dermatitis
Start: 2019-01-09End: 2025-11-11Target: 380Updated: 2025-07-15
A Study to Assess the Effect of Upadacitinib in Atopic Dermatitis-induced Sleep Disturbance in Adults With Moderate to Severe Atopic Dermatitis
WithdrawnNCT06390722
AbbVieAtopic Dermatitis, Sleep Disturbance
Start: 2024-05-23End: 2026-07-08Updated: 2024-09-19
Long Covid (LC)-REVITALIZE - A Long Covid Repurposed Drug Study
RecruitingNCT06928272
Douglas D. FraserLong COVID
Start: 2025-09-10End: 2027-12-01Target: 348Updated: 2026-04-03
Long Covid (LC)-Revitalize - A Long Covid Repurposed Drug Study
WithdrawnCTIS2025-522611-42-00
Dr. Douglas D. FraserLong Covid
Target: 75Updated: 2026-02-25

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