Piperacillin-tazobactam

DRUG20 trials

Sponsors

European Organisation for Research and Treatment of Cancer - EORTC, Wyeth is now a wholly owned subsidiary of Pfizer, Phillip Brian Smith, Melinta Therapeutics, Inc., St. Justine's Hospital

Conditions

Acute Kidney InjuryAcute PyelonephritisAmikacinAmoxicillin-clavulanateBone Marrow SuppressionCefazolinCiprofloxacinCommunity-acquired Pneumonia, Influenza, COVID-19

Phase 1

Pharmacokinetics and Safety of Piperacillin-tazobactam in Neonates

CompletedNCT00873327

Phillip Brian SmithSepsis

Start: 2009-10-31End: 2010-07-31Updated: 2018-10-03

Safety and Pharmacokinetics of Piperacillin-tazobactam Extended Infusion in Infants and Children (PIP-TAZO)

St. Justine's HospitalInfection

Start: 2016-01-31End: 2018-12-31Target: 141Updated: 2018-04-19

Phase 2

Safety and Efficacy of ZTI-01 (IV Fosfomycin) vs Piperacillin/Tazobactam for Treatment cUTI/AP Infections

CompletedNCT02753946

Nabriva Therapeutics AGAcute Pyelonephritis, Urinary Tract Infection Complicated, Urinary Tract Infection Symptomatic

Start: 2016-04-30End: 2017-05-30Updated: 2019-03-07

Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant

Active, not recruitingNCT03078010

Memorial Sloan Kettering Cancer CenterFebrile Neutropenia, Intestinal Microbiome

Start: 2017-02-10End: 2027-02-01Updated: 2026-03-04

Comparative Study To Determine The Efficacy, Safety, And Tolerability Of Ceftolozane-Tazobactam

CompletedNCT03485950

M.D. Anderson Cancer CenterOther Infectious Diseases

Start: 2018-05-16End: 2022-02-16Updated: 2022-03-15

Fecal Transplant +/- Gut Decontamination in Preventing Acute Graft Versus Host Disease in Patients Given Broad-Spectrum Antibiotics

WithdrawnNCT03862079

M.D. Anderson Cancer CenterGraft-versus-host Disease Prevention

Start: 2020-06-01End: 2021-12-31Updated: 2020-03-04

PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

CompletedNCT04983901

M.D. Anderson Cancer CenterHematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm

Start: 2021-09-14End: 2023-10-06Updated: 2024-11-04

Phase 3

Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count

CompletedNCT00003805

European Organisation for Research and Treatment of Cancer - EORTCBone Marrow Suppression, Fever, Sweats, and Hot Flashes, Infection +6

Start: 1997-11-30Updated: 2012-09-24

Efficacy/Safety of Meropenem-Vaborbactam Compared to Piperacillin-Tazobactam in Adults With cUTI and AP

CompletedNCT02166476

Melinta Therapeutics, Inc.Acute Pyelonephritis, Urinary Tract Infection Complicated

Start: 2014-11-20End: 2016-04-28Updated: 2018-06-11

Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

RecruitingNCT02735707

UMC UtrechtCommunity-acquired Pneumonia, Influenza, COVID-19

Start: 2016-04-11End: 2028-02-29Target: 20000Updated: 2024-07-12

PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock

CompletedNCT02820987

Centre Hospitalier Universitaire de BesanconSeptic Shock

Start: 2016-09-27End: 2018-10-04Updated: 2025-01-16

Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy?

CompletedNCT03269994

Memorial Sloan Kettering Cancer CenterPancreas Cancer, Pancreatic Cancer, Pancreatic Diseases

Start: 2017-11-21End: 2025-01-28Updated: 2025-10-21

Phase 4

Piperacillin/Tazobactam in Critically Ill Patients With Severe Sepsis and Septic Shock

CompletedNCT02730624

Sutep JaruratanasirikulEarly Phase of Severe Sepsis and Septic Shock

Start: 2014-03-31End: 2017-01-31Updated: 2017-09-20

Aminoglycosides in Early Sepsis

Not yet recruitingNCT06712641

University Hospital, AkershusSepsis

Start: 2026-04-01End: 2033-05-01Target: 1900Updated: 2026-03-16

A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients

RecruitingNCT06954129

University of PennsylvaniaAcute Kidney Injury

Start: 2026-01-28End: 2029-07-01Target: 750Updated: 2026-02-13

Unknown Phase

Study Evaluating Piperacillin-Tazobactam on Certain Bacteria in Hematology and Oncology Units

CompletedNCT00167999

Wyeth is now a wholly owned subsidiary of PfizerEscherichia Coli Infections, Gram-Positive Bacterial Infections, Klebsiella Infections

Start: 2005-02-28Target: 200Updated: 2007-03-15

Study Comparing Piperacillin-tazobactam Versus Piperacillin-tazobactam Plus Glycopeptide in Neutropenic Patients

CompletedNCT00195533

Wyeth is now a wholly owned subsidiary of PfizerHematological Malignancy, Leukemia, Lymphoma +3

Start: 2001-07-31End: 2005-03-31Updated: 2009-11-16

Pharmacokinetics of Antibiotics During Extracorporeal Membrane Oxygenation (ECMO) Support

TerminatedNCT03922451

Boston Children's HospitalDrug Effect

Start: 2019-08-27End: 2022-02-28Updated: 2022-03-21

Efficacy of Piperacillin-tazobactam as Empirical Antimicrobial Therapy for VAP Among ESBL-E Carriers.

CompletedNCT04276480

University Hospital, BordeauxEnterobacteriaceae Infections

Start: 2022-02-16End: 2024-04-22Updated: 2024-08-28

Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)

RecruitingNCT06426836

University Hospital, GhentAmikacin, Amoxicillin-clavulanate, Cefazolin +6

Start: 2016-08-19End: 2026-07-01Target: 300Updated: 2026-01-16

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