Mebendazole

DRUG18 trials

Conditions

AmoebiasisAnaplastic AstrocytomaAnaplastic OligodendrogliomaAncylostoma CaninumAncylostoma CeylanicumAncylostoma DuodenalAnemiaAscaris Lumbricoides

Phase 1

Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide

CompletedNCT01729260

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNewly Diagnosed High-Grade Glioma

Start: 2013-04-04End: 2021-04-16Updated: 2021-05-07

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

CompletedNCT01837862

Julie KrystalAnaplastic Astrocytoma, Brainstem Glioma, Diffuse Intrinsic Pontine Glioma +9

Start: 2013-10-22End: 2024-04-30Target: 36Updated: 2024-07-05

Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

CompletedNCT02644291

Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsAnaplastic Astrocytoma, Anaplastic Oligodendroglioma, Astrocytoma, Grade III +5

Start: 2016-05-31End: 2022-06-09Updated: 2022-06-23

Phase 2

Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm

CompletedNCT03995680

Swiss Tropical & Public Health InstituteHookworm Infections

Start: 2019-07-12End: 2019-10-09Updated: 2020-07-20

Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris Trichiura

CompletedNCT06720259

Jennifer KeiserAscaris Lumbricoides Infection, Hookworm Infection, Trichuris Trichiura; Infection

Start: 2025-04-16End: 2025-05-28Updated: 2025-06-08

Phase 3

Severe Anemia Treatment Trials, Pakistan

CompletedNCT00116493

Johns Hopkins Bloomberg School of Public HealthAnemia

Start: 2004-04-30End: 2007-05-31Updated: 2012-04-09

A Safety Study of Mebendazole in Children 2 to 10 Years of Age

CompletedNCT01173562

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.Healthy Volunteers

Start: 2010-02-28End: 2010-03-31Updated: 2014-03-12

A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants

CompletedNCT02034162

Janssen Research & Development, LLCHelminth Infections

Start: 2014-12-31End: 2015-09-30Updated: 2016-11-04

Mebendazole as Adjuvant Treatment for Colon Cancer

RecruitingNCT03925662

Sherief Abd-ElsalamColorectal Cancer

Start: 2019-04-01End: 2028-12-31Target: 40Updated: 2019-04-24

Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections

Enrolling by invitationNCT06736691

Swiss Tropical & Public Health InstituteAscaris Lumbricoides Infection, Hookworm Infection, Trichuris Trichiura; Infection

Start: 2025-11-25End: 2026-07-31Target: 315Updated: 2026-01-07

Phase 4

The Effect of a Deworming Intervention to Improve Early Childhood Growth and Development in Resource-poor Areas

CompletedNCT01314937

McGill University Health Centre/Research Institute of the McGill University Health CentreIntestinal Diseases, Parasitic, Malnutrition

Start: 2011-09-30End: 2013-07-31Target: 1760Updated: 2014-08-26

Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2

CompletedNCT01379326

University GhentAncylostoma Caninum, Ancylostoma Ceylanicum, Ancylostoma Duodenal +5

Start: 2011-12-31End: 2012-12-31Updated: 2014-12-05

Study to Evaluate Efficacy and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population

CompletedNCT02385058

Janssen-Cilag Ltd.Amoebiasis, Helminthiasis

Start: 2005-10-31End: 2006-01-31Updated: 2015-04-14

Mebendazole Study Against Hookworm Infections in Children and Adolescents in Ghana

WithdrawnNCT03261596

PATHHookworm Infections

Start: 2017-09-30End: 2017-12-31Updated: 2017-11-17

Triple Combinations Against Hookworm Infections in Lao

CompletedNCT03278431

Swiss Tropical & Public Health InstituteHookworm Infection

Start: 2017-09-27End: 2017-12-01Updated: 2018-05-08

Unknown Phase

Safety and Efficacy of Drug Combinations Against Trichuris Trichiura

CompletedNCT01050452

DBL -Institute for Health Research and DevelopmentParasitic Diseases

Start: 2007-10-31End: 2009-08-31Target: 750Updated: 2010-01-15

To Study the Effects of Addition of Mebendazole to Lenvatinib in Cirrhotics With Advanced Hepatocellular Carcinoma.

NCT04443049

Institute of Liver and Biliary Sciences, IndiaHepatocellular Carcinoma, Liver Cirrhosis

Start: 2020-07-10End: 2022-06-19Target: 170Updated: 2021-10-05

Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine

RecruitingNCT06335160

Tanta UniversityUlcerative Colitis

Start: 2024-04-20End: 2026-05-01Target: 46Updated: 2026-02-06

Pediatric Blood & Cancer2024-01-177 citations

EPCT-02. A Phase 1 Study of Mebendazole with Bevacizumab and Irinotecan in High Grade Gliomas

Neuro-Oncology2022-06-01

Mebendazole; from an anti-parasitic drug to a promising candidate for drug repurposing in colorectal cancer.

2022-04-0318 citations

Efficacy, safety and acceptability of a new chewable formulation <i>versus</i> the solid tablet of mebendazole against hookworm infections in children: An open-label, randomized controlled trial.

2020-09-2011 citations

Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate against hookworm infections in school-aged children in Laos: a randomised, single-blind trial.

2018-04-1619 citations

The Effect of Deworming on Growth in One-Year-Old Children Living in a Soil-Transmitted Helminth-Endemic Area of Peru: A Randomized Controlled Trial

PLoS neglected tropical diseases2015-10-0141 citations