Ibudilast

DRUG13 trials

Sponsors

University of Adelaide, Parisa Gazerani, University of California, Los Angeles, MediciNova, VA Office of Research and Development

Conditions

Alcohol Use DisorderAlcohol Use Disorder (AUD)Alcohol Use DisordersAlcoholismAmyotrophic Lateral SclerosisHIV InfectionLong COVIDMedication Overuse Headache

Phase 1

Ibudilast in the Treatment of Medication Overuse Headache

University of AdelaideMedication Overuse Headache

Start: 2011-04-30End: 2013-08-31Target: 40Updated: 2013-02-06

Ibudilast in the Treatment of Patients With Chronic Migraine.

CompletedNCT01389193

Parisa GazeraniMigraine Headache

Start: 2013-06-30End: 2015-12-31Updated: 2015-12-29

Development of Ibudilast for Alcohol Use Disorder

CompletedNCT02025998

University of California, Los AngelesAlcohol Use Disorders

Start: 2013-12-31End: 2015-06-30Updated: 2016-02-23

A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS)

CompletedNCT02714036

MediciNovaAmyotrophic Lateral Sclerosis

Start: 2016-05-06End: 2020-06-30Updated: 2024-09-24

A Biomarker Study to Evaluate MN-166 in Subjects With Amyotrophic Literal Sclerosis (ALS)

CompletedNCT02714036

MediciNovaAmyotrophic Lateral Sclerosis

Start: 2016-05-06End: 2020-06-30Updated: 2024-09-24

Phase 2

Trial of Ibudilast for Methamphetamine Dependence

CompletedNCT01860807

University of California, Los AngelesHIV Infection, Methamphetamine Dependence

Start: 2013-07-31End: 2017-12-31Updated: 2019-01-30

Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis

CompletedNCT01982942

MediciNovaMultiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive

Start: 2013-11-30End: 2017-12-31Updated: 2020-07-28

Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users

CompletedNCT03341078

VA Office of Research and DevelopmentMethamphetamine-dependence

Start: 2019-05-01End: 2025-10-15Updated: 2026-02-02

Ibudilast and Withdrawal-Related Dysphoria

CompletedNCT03489850

University of California, Los AngelesAlcohol Use Disorder

Start: 2018-07-16End: 2020-03-31Updated: 2021-10-07

Ibudilast for the Treatment of Alcohol Use Disorder

CompletedNCT03594435

University of California, Los AngelesAlcohol Use Disorder

Start: 2018-10-01End: 2023-04-19Updated: 2024-11-27

Efficacy, Safety, Tolerability, and Biomarkers of Ibudilast (MN-166) in Patients Hospitalized With COVID-19 at Risk for ARDS

CompletedNCT04429555

MediciNovaPneumonia, Viral

Start: 2021-01-11End: 2024-08-07Updated: 2024-10-30

Ibudilast for Treating Alcohol Use Disorder

Active, not recruitingNCT05414240

University of PennsylvaniaAlcoholism, Alcohol Use Disorder (AUD)

Start: 2023-01-14End: 2027-12-31Target: 50Updated: 2026-06-03

RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine

CompletedNCT05513560

University Health Network, TorontoLong COVID, Post Acute Sequelae of COVID-19, Post COVID Condition

Start: 2023-05-31End: 2025-12-31Updated: 2026-02-23

Phase 3

Regeneration in Cervical Degenerative Myelopathy

RecruitingNCT04631471

Cambridge University Hospitals NHS Foundation TrustMyelopathy, Spinal Cord Diseases

Start: 2021-12-22End: 2026-09-01Target: 400Updated: 2022-01-13

Related Papers

Effect of MN-166 (ibudilast) on acute respiratory failure prevention in hospitalized participants with COVID-19: a randomized, double-blind, placebo-controlled phase 2 study

BMC Pulmonary Medicine2026-04-02

Peripheral inflammation mediates the relationship between early life stress and alcohol use.

2026-01-28

Evaluation of cortical pathology in primary-progressive multiple sclerosis: a post hoc analysis of the SPRINT-MS trial.

2026-01-05

Effect of Ibudilast vs Placebo on GFAP and Contactin levels in a phase 2 clinical trial in progressive multiple sclerosis.

2025-11-21

A Neuroimmune Modulator for Alcohol Use Disorder

JAMA Network Open2025-04-309 citations

Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder

Neuropsychopharmacology2024-05-1313 citations

Sex differences in neural response to an acute stressor in individuals with an alcohol use disorder

Alcohol Clinical and Experimental Research2024-04-234 citations

Reward, relief, and habit drinking profiles in treatment seeking individuals with an AUD

Alcohol and Alcoholism2024-03-168 citations

Effect of ibudilast on thalamic magnetization transfer ratio and volume in progressive multiple sclerosis

Multiple Sclerosis Journal2023-08-036 citations

Targeting patient recovery priorities in degenerative cervical myelopathy: design and rationale for the RECEDE-Myelopathy trial—study protocol

BMJ Open2023-03-0110 citations

Ibudilast attenuates alcohol cue–elicited frontostriatal functional connectivity in alcohol use disorder

Alcoholism Clinical and Experimental Research2021-09-2927 citations

Neurofilament light chain in a phase 2 clinical trial of ibudilast in progressive multiple sclerosis

Multiple Sclerosis Journal2021-02-2643 citations

Optical coherence tomography outcomes from SPRINT-MS, a multicenter, randomized, double-blind trial of ibudilast in progressive multiple sclerosis

Multiple Sclerosis Journal2020-10-1525 citations

Ibudilast for alcohol use disorder: study protocol for a phase II randomized clinical trial.

2020-09-1111 citations

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

New England Journal of Medicine2018-08-29268 citations