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HTX-011

DRUG17 trials

Sponsors

Heron Therapeutics, Mayo Clinic

Conditions

AnalgesiaLumbar LaminectomyMultimodal AnalgesiaPost-Operative PainPostoperative PainTotal Knee ArthroplastyTotal Shoulder Arthroplasty

Phase 2

HTX-011 for Post-bunionectomy Analgesia
CompletedNCT02471898
Heron TherapeuticsAnalgesia
Start: 2015-06-01End: 2015-09-01Updated: 2026-07-17
Pilot Herniorrhaphy Study for Postoperative Analgesia
CompletedNCT02504580
Heron TherapeuticsPostoperative Pain
Start: 2015-07-01End: 2017-04-01Updated: 2026-03-02
Phase 2B Upper Extremity Nerve Block Study
CompletedNCT03011333
Heron TherapeuticsPostoperative Pain
Start: 2017-01-14End: 2018-03-19Updated: 2026-03-02
Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia
CompletedNCT03015532
Heron TherapeuticsPostoperative Pain
Start: 2017-01-13End: 2018-05-16Updated: 2026-03-02
Phase 2 Herniorrhaphy Study for Opioid Elimination
CompletedNCT03695367
Heron TherapeuticsPostoperative Pain
Start: 2018-10-01End: 2018-12-15Updated: 2026-03-02
Phase 2 Bunionectomy HTX-011 Administration Study
CompletedNCT03718039
Heron TherapeuticsPostoperative Pain
Start: 2018-10-24End: 2019-03-11Updated: 2026-03-02
Pediatric Postoperative Analgesia Herniorrhaphy Study
WithdrawnNCT03922048
Heron TherapeuticsAnalgesia
Start: 2023-07-01End: 2025-12-01Updated: 2026-05-12
HTX-011 Administration Study in Planned Caesarean Section Procedure
CompletedNCT03955211
Heron TherapeuticsAnalgesia
Start: 2019-06-24End: 2021-12-27Updated: 2022-03-14
HTX-011 in Spinal Surgery
CompletedNCT04911062
Heron TherapeuticsLumbar Laminectomy, Post-Operative Pain
Start: 2022-04-07End: 2022-08-26Updated: 2023-06-12

Phase 3

Phase 3 Herniorrhaphy Study for Postoperative Analgesia (EPOCH 2)
CompletedNCT03237481
Heron TherapeuticsPostoperative Pain
Start: 2017-07-31End: 2018-01-16Updated: 2026-03-02
Bunionectomy Study for Postoperative Analgesia (EPOCH 1)
CompletedNCT03295721
Heron TherapeuticsPostoperative Pain
Start: 2017-10-24End: 2018-03-13Updated: 2026-03-02
Study of Post-Herniorrhaphy Non-opioid MMA Regimens
CompletedNCT03907176
Heron TherapeuticsAnalgesia
Start: 2019-04-04End: 2021-11-22Updated: 2026-06-04
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
CompletedNCT03974932
Heron TherapeuticsAnalgesia
Start: 2019-06-05End: 2021-01-07Updated: 2026-03-02

Phase 4

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.
NCT05109312
Heron TherapeuticsAnalgesia
Start: 2021-10-12End: 2024-06-30Target: 90Updated: 2023-10-26
Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty
CompletedNCT05188053
Mayo ClinicTotal Knee Arthroplasty
Start: 2022-03-11End: 2024-04-18Updated: 2025-04-27
A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE.
CompletedNCT06109415
Heron TherapeuticsMultimodal Analgesia, Postoperative Pain, Total Shoulder Arthroplasty
Start: 2021-10-20End: 2022-07-29Updated: 2023-10-31
A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE
CompletedNCT06109428
Heron TherapeuticsAnalgesia
Start: 2021-10-12End: 2022-04-07Updated: 2023-10-31

Related Papers

HTX-011 in Combination with Multimodal Analgesic Regimen Minimized Severe Pain and Opioid Use after Total Knee Arthroplasty in an Open-Label Study
The Journal of Knee Surgery2022-06-103 citations
Opioid-Free Recovery After Hernia Repair with HTX-011 as the Foundation of a Non-Opioid, Multimodal Analgesia Regimen in a Real-World Setting: A Randomized, Open-Label Study.
2021-07-276 citations
HTX-011 Effectively Reduces Postoperative Pain Intensity and Opioid use in the Elderly
Pain Management2021-07-218 citations
HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in herniorrhaphy: results from the phase 3 EPOCH 2 study.
2019-08-1941 citations
HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study
Regional Anesthesia & Pain Medicine2019-05-2152 citations