GnRH

DRUG15 trials

Conditions

AgonadismAmenorrheaAndrogen DeficiencyCancerCardiovascular DiseasesDelayed PubertyDiabetesFertility

Phase 1

Kisspeptin Administration in the Adult

CompletedNCT00914823

Massachusetts General HospitalGnRH Deficiency, Hyperprolactinemia, Hypogonadotropic Hypogonadism +3

Start: 2009-06-23End: 2021-10-22Updated: 2024-07-31

Elucidating Kisspeptin Physiology by Blocking Kisspeptin Signaling

CompletedNCT01438073

Massachusetts General HospitalAgonadism, Healthy Postmenopausal Women, Hypogonadotropic Hypogonadism

Start: 2011-09-30End: 2016-04-30Updated: 2022-07-11

Kisspeptin in the Evaluation of Delayed Puberty

CompletedNCT01438034

Massachusetts General HospitalDelayed Puberty, GnRH Deficiency, Hypogonadotropic Hypogonadism +1

Start: 2013-06-08End: 2021-09-10Updated: 2023-10-19

Neuropeptides in Human Reproduction

CompletedNCT01952782

Massachusetts General HospitalHypogonadotropic Hypogonadism

Start: 2014-04-30End: 2016-05-31Updated: 2024-07-31

Recall by Genotype: Neuropeptide Stimulation

TerminatedNCT05901467

Stephanie B. Seminara, MDReproductive Disorder

Start: 2023-10-20End: 2024-05-29Updated: 2026-03-06

Phase 2

Pulsatile GnRH in Anovulatory Infertility

NCT00383656

Massachusetts General HospitalAmenorrhea, Hypogonadotropic Hypogonadism, Kallmann's Syndrome

Start: 1989-01-31End: 2020-09-30Target: 270Updated: 2017-07-12

The Effects of Aging and Estrogen on the Pituitary

NCT00386022

Massachusetts General HospitalHealthy

Start: 2002-01-31End: 2018-01-31Updated: 2017-04-13

Rapid Hormonal Cycling as Treatment for Patients With Prostate Cancer: The Men's Cycle

CompletedNCT00586898

Memorial Sloan Kettering Cancer CenterCancer, Hormonal Cycling, Prostate

Start: 2001-07-31End: 2009-03-31Updated: 2016-03-25

Administration of Kisspeptin in Patients With Hyperprolactinemia

CompletedNCT02956447

Massachusetts General HospitalHyperprolactinemia, Hypogonadism

Start: 2017-11-17End: 2023-07-29Updated: 2024-10-01

Randomized Phase II Study of Salvage XRT + ADT +/- Abiraterone and Apalutamide for Rising PSA After RP (FORMULA-509)

Active, not recruitingNCT03141671

Dana-Farber Cancer InstituteProstate Cancer

Start: 2017-11-24End: 2025-12-31Updated: 2024-05-14

Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism

CompletedNCT04648969

Stephanie B. Seminara, MDHypogonadotropic Hypogonadism

Start: 2019-05-03End: 2025-08-31Updated: 2026-02-18

Phase 4

GnRH for Luteal Support in IVF/ICSI/FET Cycles

RecruitingNCT02357654

University Reproductive AssociatesInfertility

Start: 2015-11-30End: 2026-07-31Target: 350Updated: 2025-08-01

Unknown Phase

Effects of Dietary Omega-3 Fatty Acids on Reproductive Hormones in Obese Women

CompletedNCT01894581

University of Colorado, DenverFertility, Obesity

Start: 2014-07-31End: 2014-12-31Updated: 2017-02-02

Reprometabolic Syndrome Mediates Subfertility in Obesity

Active, not recruitingNCT02653092

University of Colorado, DenverHyperinsulinemia, Hypogonadotropic Hypogonadotropism, Infertility +1

Start: 2016-06-01End: 2026-12-11Updated: 2026-03-02

Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men

NCT05773183

Royal College of Surgeons, IrelandAndrogen Deficiency, Cardiovascular Diseases, Diabetes +8

Start: 2023-03-12End: 2024-08-31Target: 60Updated: 2023-03-17

2025-11-22

Sex-dependent increases in oxytocin levels in response to intravenous kisspeptin in humans

European Journal of Endocrinology2025-02-187 citations

Analysis of Inflammatory Markers in Response to Induction of Reprometabolic Syndrome by a Eucaloric High Fat Diet in Normal Weight Women.

2024-05-06

Patient-reported health-related quality of life (HRQoL) in the randomized FORMULA-509 trial of salvage radiotherapy and 6 months of GnRH agonist with either bicalutamide or abiraterone acetate plus prednisone (AAP) and apalutamide (Apa) after radical prostatectomy (RP).

Journal of Clinical Oncology2024-01-291 citations

FORMULA-509: A multicenter randomized trial of post-operative salvage radiotherapy (SRT) and 6 months of GnRH agonist with or without abiraterone acetate/prednisone (AAP) and apalutamide (Apa) post-radical prostatectomy (RP).

Journal of Clinical Oncology2023-02-2025 citations

Gonadotropin response to insulin and lipid infusion reproduces the reprometabolic syndrome of obesity in eumenorrheic lean women: a randomized crossover trial

Fertility and Sterility2021-04-0819 citations

OR11-01 Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay

Journal of the Endocrine Society2020-04-01

A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA).

2019-06-135 citations

Divergent responses to kisspeptin in children with delayed puberty.

2018-04-1914 citations