Infertility
Conditions
Brief summary
During IVF cycles an embryo is generally placed into the uterine cavity between 3 and 5 days after fertilization. For a successful pregnancy to take place, that embryo must then implant in the properly primed and staged endometrium, which subsequently must continue to develop to accommodate the growing and maturing embryo and then fetus. This process is normally regulated by hormonal interactions between the fetal, endometrial and luteal tissue. It has been found that after IVF additional support for the endometrium with progesterone improves implantation and subsequent live birth rates in IVF cycle . Recent data has shown that additional supplementation with a single administration of a GnRH agonist around the time the time of embryo transfer may further enhance these rates .
Detailed description
see above
Interventions
DRUGGnRH
single shot of GnRH agonist
DRUGplacebo
placebo
Sponsors
University Reproductive Associates
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* women undergoing IVF/ICSI or frozen embryo transfers (FET) that less than 40 years old.
Exclusion criteria
* day 3 transfers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth per transfer | 9 months |
Secondary
| Measure | Time frame |
|---|---|
| implantation rates | 4 weeks |
| clinical pregnancy | 4 weeks |
| rates of OHSS | 4 weeks |
Countries
United States
Contacts
Primary ContactPeter G McGovern, MD
Outcome results
None listed