Gamma Knife Radiosurgery

PROCEDURE16 trials

Sponsors

Umekawa Motoyuki, University of California, San Francisco, Assistance Publique Hopitaux De Marseille, CancerCare Manitoba, Yale University

Conditions

AcromegalyAcromegaly Due to Pituitary AdenomaBRAFV600E Melanoma PatientsBrain MetastasesBreast CancerColorectal CancerEssential TremorGamma Knife Radiosurgery

Phase 2

Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for Recurrent Glioma

TerminatedNCT01011231

University of California, San FranciscoGlioblastoma

Start: 2009-12-31End: 2011-04-30Updated: 2013-05-06

Dabrafenib and Trametinib With Radiosurgery in Melanoma Brain Mets

TerminatedNCT01721603

University of California, San FranciscoBRAFV600E Melanoma Patients

Start: 2013-04-30End: 2016-01-31Updated: 2018-01-23

Efficacy and safety of gamma knife radiosurgery for asymptomatic intracranial hemangioblastoma in patients with von Hippel-Lindau disease: A prospective interventional trial

RecruitingJPRN-jRCT1032220685

Umekawa Motoyukiasymptomatic intracranial hemangioblastoma in patients with von Hippel-Lindau disease asymptomatic intracranial hemangioblastoma

Start: 2023-12-11Target: 20Updated: 2025-07-18

Phase 3

Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma

Samsung Medical CenterAcromegaly Due to Pituitary Adenoma

Start: 2018-03-01End: 2022-12-31Target: 90Updated: 2018-03-01

Unknown Phase

Evaluation of the Safety and Efficacy of Bilateral Subthalamic Nucleus (SNT) Radiosurgery in Idiopathic Severe Parkinson's Disease Fulfilling Inclusion Criteria for STN Deep Brain Stimulation and Presenting With a Contraindication to Intracerebral Electrode Implantation.

CompletedNCT01284699

Assistance Publique Hopitaux De MarseilleParkinson's Disease, Presenting a Contraindication to Intracerebral Electrode Implantati, With Inclusion Criteria for STN Deep Brain Stimulation

Start: 2011-02-04End: 2023-04-12Updated: 2023-04-14

Neurocognition After Gamma Knife Radiosurgery for Multiple Brian Metastases

TerminatedNCT01970644

CancerCare ManitobaNeoplasm Metastases

Start: 2014-04-30End: 2015-09-30Updated: 2016-05-30

A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection

TerminatedNCT02005614

Yale UniversityBrain Metastases, Breast Cancer, Colorectal Cancer +5

Start: 2013-11-30End: 2018-08-31Updated: 2019-07-01

Vestibular Schwannoma - Radiosurgery or Expectation: V-REX.

CompletedNCT02249572

Haukeland University HospitalVestibular Schwannoma

Start: 2014-10-01End: 2021-10-01Updated: 2025-04-02

Gamma Knife Radiosurgery for Treatment of Essential Tremor

Swedish Medical CenterEssential Tremor

Start: 2014-09-30End: 2023-12-31Target: 183Updated: 2023-01-23

Late Effects of Radiosurgery on Acromegaly Study

CompletedNCT02296216

Assistance Publique Hopitaux De MarseilleAcromegaly

Start: 2015-02-16End: 2023-04-13Updated: 2023-04-18

Cognitive Outcome After Gamma Knife Radiosurgery in Patients With Brain Metastases (CAR-Study A)

CompletedNCT02953756

Elisabeth-TweeSteden ZiekenhuisNeoplasm Metastases

Start: 2015-10-31End: 2019-10-31Updated: 2020-08-14

Cognitive Outcome After SRS or WBRT in Patients With Multiple Brain Metastases (CAR-Study B)

Elisabeth-TweeSteden ZiekenhuisNeoplasm Metastasis

Start: 2016-02-29End: 2023-12-31Updated: 2023-09-13

Evaluation of the Predictors of Clinical and Radiological Response to Gamma-Knife Radiosurgery in the Treatment of Intermediate Ventral Nucleus of the Thalamus (VIM) Thalamotomy Tremor.

Assistance Publique Hopitaux De MarseilleSevere Disabling Tremor

Start: 2017-10-23End: 2021-10-22Target: 700Updated: 2017-11-22

Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection

RecruitingNCT04857905

Medical University of ViennaBrain Metastases

Start: 2020-07-01End: 2025-12-01Target: 100Updated: 2024-01-05

Long-Term Outcomes of Hypopituitarism Following Gamma Knife Radiosurgery for Pituitary Adenomas

CompletedNCT07015645

Al-Azhar UniversityGamma Knife Radiosurgery, Hypopituitarism, Long Term +1

Start: 2019-01-01End: 2025-01-01Updated: 2025-06-11

Gamma Knife Radiosurgery on Tectal Plate Gliomas

CompletedNCT07015710

Al-Azhar UniversityGamma Knife Radiosurgery, Tectal Plate Gliomas

Start: 2021-01-01End: 2024-12-01Updated: 2025-06-11

Related Papers

Upfront Radiosurgery vs a Wait-and-Scan Approach for Small- or Medium-Sized Vestibular Schwannoma

JAMA2023-08-0147 citations

The long-term course and relationship with survival of multidimensional fatigue in patients with brain metastases after Gamma Knife radiosurgery

Journal of Cancer Research and Clinical Oncology2023-05-30

P01.06.B Interim results from CAR-Study B: An ongoing randomized trial on the effect of SRS or WBRT on cognitive performance in patients with 11-20 brain metastases

Neuro-Oncology2022-09-013 citations

Comparing the impact of upfront radiosurgery versus expectation in vestibular schwannoma (the V-REX study): protocol for a randomised, observer-blinded, 4-year, parallel-group, single-centre, superiority study

BMJ Open2021-03-013 citations

Health-related quality of life after Gamma Knife radiosurgery in patients with 1-10 brain metastases.

2020-10-067 citations

Cognitive functioning and predictors thereof in patients with 1–10 brain metastases selected for stereotactic radiosurgery

Journal of Neuro-Oncology2019-09-2421 citations

A randomised trial to compare cognitive outcome after gamma knife radiosurgery versus whole brain radiation therapy in patients with multiple brain metastases: research protocol CAR-study B.

2018-02-219 citations

BRAF inhibitor and stereotactic radiosurgery is associated with an increased risk of radiation necrosis

Melanoma Research2016-05-2593 citations