Long Term, Hypopituitarism, Gamma Knife Radiosurgery, Pituitary Adenomas
Conditions
Brief summary
This study aims to assess long-term outcomes of hypopituitarism following gamma knife radiosurgery (GKRS) for pituitary adenomas.
Detailed description
Pituitary adenomas (PAs) are one of the most common intracranial neoplasms, accounting for 10-20% of diagnosed brain tumors. Initial gamma knife radiosurgery (GKRS) can be an alternative treatment for selected NFPA patients with comorbidities, documented growth small tumors, cavernous sinus invasion, or advanced age. Hypopituitarism is one of the most common complications of radiosurgery (Cordeiro et al., 2018). Long-term follow-up is crucial to assess new pituitary deficits. Typically, hypopituitarism presents within the first 2-4 years after the treatment with radiosurgery, but the risk of pituitary insufficiency increases to up to 80%. Reports on the highest incidence of new-onset hypopituitarism also mentioned the longest follow-up period.
Interventions
PROCEDUREGamma Knife Radiosurgery
Patients received gamma knife radiosurgery (GKRS) treatment for pituitary adenomas.
Sponsors
Al-Azhar University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years. * Both sexes. * Patients treated with gamma knife radiosurgery (GKRS).
Exclusion criteria
* Patients with inadequate endocrine follow-up (\<12 months). * Patients who had undergone previous radiation therapy. * Pituitary insufficiency which presents before gamma knife radiosurgery (GKRS). * Patients without visible glands.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of new-onset hypopituitarism | 5 years post-procedure | Prevalence of new-onset hypopituitarism will be recorded. |
Countries
Egypt
Outcome results
None listed