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Fasinumab

DRUG8 trials

Sponsors

Regeneron Pharmaceuticals

Conditions

Chronic Low Back PainHealthy VolunteersLow Back PainOsteoarthritisOsteoarthritis of the Knee or HipOsteoarthritis, HipOsteoarthritis, Knee

Phase 1

Study of Fasinumab (REGN475) in Healthy Japanese and Caucasian Subjects
CompletedNCT02516618
Regeneron PharmaceuticalsHealthy Volunteers
Start: 2015-07-31End: 2016-02-29Updated: 2016-05-12

Phase 2

A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain
CompletedNCT02620020
Regeneron PharmaceuticalsLow Back Pain
Start: 2016-01-26End: 2017-09-13Updated: 2020-06-16
Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee
CompletedNCT03691974
Regeneron PharmaceuticalsOsteoarthritis, Hip, Osteoarthritis, Knee
Start: 2018-10-15End: 2021-01-07Updated: 2023-03-01
Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip
TerminatedNCT03949673
Regeneron PharmaceuticalsOsteoarthritis, Hip, Osteoarthritis, Knee
Start: 2019-04-08End: 2020-08-25Updated: 2023-10-17

Phase 3

Long-Term Safety and Efficacy Study of Fasinumab in Patients With Pain Due to Osteoarthritis (OA) of the Knee or Hip
CompletedNCT02683239
Regeneron PharmaceuticalsOsteoarthritis of the Knee or Hip
Start: 2016-02-17End: 2021-06-15Updated: 2023-10-13
A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
CompletedNCT03161093
Regeneron PharmaceuticalsOsteoarthritis, Hip, Osteoarthritis, Knee
Start: 2017-08-17End: 2021-08-27Updated: 2022-11-14
Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee
TerminatedNCT03285646
Regeneron PharmaceuticalsChronic Low Back Pain, Osteoarthritis
Start: 2017-10-30End: 2019-05-02Updated: 2021-06-30
Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip
CompletedNCT03304379
Regeneron PharmaceuticalsOsteoarthritis, Hip, Osteoarthritis, Knee
Start: 2017-10-26End: 2020-11-09Updated: 2023-02-24

Related Papers

A phase III, randomised, double-blind, multi-dose, placebo- and naproxen-controlled study to evaluate the efficacy and safety of fasinumab in patients with pain due to osteoarthritis of the knee or hip.
2026-01-16
Efficacy and safety of fasinumab in an NSAID-controlled study in patients with pain due to osteoarthritis of the knee or hip
BMC Musculoskeletal Disorders2025-02-259 citations
Prevalence of preexisting articular bone pathology in patients with osteoarthritis screened for fasinumab clinical trials identified by X-ray or magnetic resonance imaging.
2024-07-141 citations
Antibodies to watch in 2020.
2020-01-01328 citations
Fulranumab in patients with interstitial cystitis/bladder pain syndrome: observations from a randomized, double-blind, placebo-controlled study.
2017-01-0519 citations