DPP-4 inhibitor

DRUG18 trials

Sponsors

Graduate School of Medical Sciences, Kyushu University Department of Surgery and Oncology, Nihon University School of Medicine, Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital, Astellas Pharma Inc, Sanofi

Conditions

Cardiovascular EventsChronic kidney diseaseDiabetesDiabetes Mellitus, Type 2Renal DiseaseRenal Insufficiency, ChronicType 2 DiabetesType 2 Diabetes Mellitus

Phase 3

A Study to Assess the Safety and Efficacy of ASP1941 in Combination With Dipeptidyl Peptidase-4 (DPP-4) Inhibitor in Type 2 Diabetic Patients

CompletedNCT01242228

Astellas Pharma IncType 2 Diabetes Mellitus

Start: 2010-10-21End: 2012-06-06Updated: 2025-05-30

A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes

CompletedNCT02207374

Novo Nordisk A/SDiabetes, Diabetes Mellitus, Type 2

Start: 2014-08-04End: 2016-02-27Updated: 2019-01-07

Phase 4

Exploratory study on the cardiovascular system of DPP-4 inhibitors in angina patients underwent PCI after complicated with type 2 diabetes

Active, not recruitingJPRN-UMIN000011145

Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai HospitalType 2 diabetic patients with angina pectoris who undergo percutaneous coronary intervention

Start: 2013-07-08Target: 20Updated: 2025-07-18

Efficacy and Safety of Insulin Glargine in Patients With Type 2 Diabetes With Inadequate Control on DPP-4 Inhibitor Therapy

CompletedNCT02027753

SanofiDiabetes Mellitus, Type 2

Start: 2013-12-31End: 2015-04-30Updated: 2015-08-27

Approaches To Therapy Escalation In T2D

WithdrawnNCT03813316

LMC Diabetes & Endocrinology Ltd.Type2 Diabetes

Start: 2019-05-01End: 2019-09-18Updated: 2019-09-27

Unknown Phase

The efficacy of DPP-4 inhibitor after pancreatectomy

Active, not recruitingJPRN-UMIN000003722

Graduate School of Medical Sciences, Kyushu University Department of Surgery and Oncologybebign diseases of pancreas 1)Serous cyst adenoma 2) Mucinous cyst adenoma 3) Lymphoepithelial cyst 4)Intraductal papillary mucinous neoplasm

Start: 2010-07-01Target: 20Updated: 2025-07-18

Efficacy and safety of DPP-4 inhibitors in patients with chronic kidney disease

RecruitingJPRN-UMIN000009493

Nihon University School of MedicineChronic kidney disease

Start: 2011-09-01Target: 30Updated: 2025-07-18

Comparative Effectiveness of Empagliflozin in the US

Active, not recruitingNCT03363464

Boehringer IngelheimDiabetes Mellitus, Type 2

Start: 2017-10-16End: 2026-04-30Updated: 2026-02-18

GA 6: The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide

CompletedNCT03845179

University Hospital, Gentofte, CopenhagenType2 Diabetes

Start: 2019-05-29End: 2020-02-28Updated: 2021-03-16

Comparative Effectiveness of Metformin for Type 2 Diabetes With Chronic Kidney Disease

CompletedNCT03921242

Weill Medical College of Cornell UniversityDiabetes Mellitus, Type 2, Renal Insufficiency, Chronic

Start: 2019-08-01End: 2023-08-01Updated: 2023-11-09

Replication of the CANVAS Diabetes Trial in Healthcare Claims

CompletedNCT03936010

Brigham and Women's HospitalDiabetes

Start: 2017-09-22End: 2021-02-18Updated: 2023-07-27

Replication of the LEADER Diabetes Trial in Healthcare Claims

CompletedNCT03936049

Brigham and Women's HospitalDiabetes

Start: 2017-09-22End: 2021-02-18Updated: 2023-07-27

Replication of the DECLARE Diabetes Trial in Healthcare Claims

CompletedNCT04215523

Brigham and Women's HospitalDiabetes

Start: 2019-07-08End: 2021-02-18Updated: 2023-07-27

Replication of the EMPAREG Diabetes Trial in Healthcare Claims

CompletedNCT04215536

Brigham and Women's HospitalDiabetes

Start: 2019-07-08End: 2021-02-18Updated: 2023-07-27

Comparative Effectiveness of Dapagliflozin Versus DPP-4 Inhibitors

CompletedNCT04304430

University of PadovaType 2 Diabetes

Start: 2018-10-18End: 2020-02-29Updated: 2020-03-11

Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study

Active, not recruitingNCT05220917

Brigham and Women's HospitalCardiovascular Events, Renal Disease, Type2 Diabetes

Start: 2021-08-01End: 2026-07-01Target: 781430Updated: 2025-12-08

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Semaglutide v DPP4 Inhibitors

CompletedNCT05768945

Brigham and Women's HospitalDiabetes

Start: 2022-11-30End: 2023-12-31Updated: 2025-11-07

Korean Study on Safety and Effectiveness of OAD Triple Therapy in Type 2 Diabetes

RecruitingNCT06838286

Chong Kun Dang PharmaceuticalDiabetes Mellitus, Type 2

Start: 2024-03-16End: 2029-12-31Target: 10000Updated: 2025-02-20

Related Papers

Safety profile of semaglutide in people aged 55 years and over: pooled data from the PIONEER, SUSTAIN and STEP phase 3 clinical programmes

Alzheimer s & Dementia2023-12-012 citations

Emulating Randomized Clinical Trials With Nonrandomized Real-World Evidence Studies

Circulation2020-12-17279 citations

Effects of semaglutide on risk of cardiovascular events across a continuum of cardiovascular risk: combined post hoc analysis of the SUSTAIN and PIONEER trials

Cardiovascular Diabetology2020-09-3056 citations

Empagliflozin and the Risk of Heart Failure Hospitalization in Routine Clinical Care

Circulation2019-04-08212 citations

Semaglutide s.c. Once-Weekly in Type 2 Diabetes: A Population Pharmacokinetic Analysis.

2018-06-1535 citations