Dofetilide

DRUG5 trials

Sponsors

ProRhythm, Inc., Food and Drug Administration (FDA), Gilead Sciences, Samir Saba

Conditions

Atrial FibrillationDrug-induced QT ProlongationDrug-induced Surface ECG ChangesLong QT SyndromePharmacodynamicsPharmacokinetics

Phase 1

Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects

CompletedNCT01873950

Food and Drug Administration (FDA)Drug-induced Surface ECG Changes

Start: 2013-05-31End: 2014-12-31Updated: 2018-03-08

Ability of Late Sodium or Calcium Current Block to Balance the ECG Effects of Potassium Current Block

CompletedNCT02308748

Food and Drug Administration (FDA)Drug-induced QT Prolongation, Pharmacodynamics, Pharmacokinetics

Start: 2014-05-31End: 2014-06-30Updated: 2016-06-08

Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults

CompletedNCT02365532

Gilead SciencesLong QT Syndrome

Start: 2015-02-28End: 2015-05-31Updated: 2015-05-20

Phase 3

High Intensity Focused Ultrasound (HIFU) Ablation System Study

SuspendedNCT00392106

ProRhythm, Inc.Atrial Fibrillation

Start: 2006-04-30End: 2011-06-30Target: 240Updated: 2008-06-17

Unknown Phase

Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients

CompletedNCT04128878

Samir SabaAtrial Fibrillation

Start: 2019-05-01End: 2020-12-31Updated: 2021-01-14

Related Papers

Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk

Circulation2017-02-18123 citations

Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block

PLoS ONE2016-12-3037 citations

Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk

PLoS ONE2016-12-3035 citations

Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

Journal of the American Heart Association2015-04-14126 citations