Bumetanide

DRUG19 trials

Conditions

Alzheimer DiseaseAutismAutism Spectrum DisorderAutistic DisorderAutistics ChildrenChronic Kidney InsufficiencyCirrhosisDown Syndrome

Phase 1

Pilot Study of Bumetanide for Newborn Seizures

CompletedNCT00830531

Soul, Janet , M.D.Seizures

Start: 2010-01-31End: 2019-01-31Updated: 2020-12-17

Study to Evaluate the Potential Pharmacokinetic Interaction and Pharmacodynamic Effects on Renal Parameters of Bumetanide (1mg) and Dapagliflozin (10 mg) When Co-administered in Healthy Subjects

CompletedNCT00930865

AstraZenecaType 2 Diabetes Mellitus

Start: 2009-07-31End: 2009-09-30Updated: 2016-10-17

NEMO1:NEonatal Seizure Using Medication Off-patent

CompletedNCT01434225

Great Ormond Street Hospital for Children NHS Foundation TrustNeonatal Seizures

Start: 2011-08-31End: 2013-06-30Updated: 2015-09-14

Delivering a Diuretic Into the Liver Artery Followed by Plugging up the Artery to Starve Out Liver Cancer Cells

Active, not recruitingNCT03107416

Memorial Sloan Kettering Cancer CenterUnresectable Hepatocellular Carcinoma

Start: 2017-04-05End: 2026-04-05Updated: 2025-05-01

Phase 2

Bumetanide in Hypokalaemic Periodic Paralysis

TerminatedNCT02582476

University College, LondonHypokalemic Periodic Paralysis

Start: 2015-01-31End: 2017-05-09Target: 12Updated: 2018-02-07

Evaluation of the Efficiency of Treatment by BUMETANIDE on Autistic Children With a Known Ethiology

WithdrawnNCT02947880

University Hospital, LimogesAutistic Disorder

Start: 2016-12-31End: 2020-06-30Updated: 2021-06-02

A Study of Bumetanide for the Treatment of Autism Spectrum Disorders

CompletedNCT03156153

Xinhua Hospital, Shanghai Jiao Tong University School of MedicineAutism Spectrum Disorder

Start: 2017-05-24End: 2019-07-10Updated: 2021-03-01

Bumetanide in Autism Medication and Biomarker study

Active, not recruitingNL-OMON44696

Universitair Medisch Centrum Utrechtautism autism spectrum disorders

Start: 2016-06-21Target: 90Updated: 2024-02-28

Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial

CompletedNCT03923933

Hospital General de México Dr. Eduardo LiceagaRenal Insufficiency, Chronic

Start: 2019-06-18End: 2019-10-28Updated: 2020-11-23

A Study of Ultra High Dose Diuretics to Treat Heart Failure

CompletedNCT06036914

Mayo ClinicHeart Failure; With Decompensation

Start: 2023-11-27End: 2024-10-08Updated: 2026-01-14

Bumetanide in Patients With Alzheimer's Disease

RecruitingNCT06052163

Stanford UniversityAlzheimer Disease

Start: 2023-04-10End: 2026-12-15Target: 40Updated: 2026-01-14

Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome

RecruitingNCT06465823

Stefano VicariDown Syndrome

Start: 2023-01-11End: 2026-09-30Target: 64Updated: 2024-06-20

Efficacy of Bumetanide in Children With Autism Spectrum Disorder Guided by Peripheral Blood Biomarkers and Machine Learning Models

RecruitingNCT07005414

Fei LiAutism Spectrum Disorder

Start: 2025-06-04End: 2026-05-30Target: 66Updated: 2025-06-12

Phase 3

Bumetanide Versus Furosemide in Heart Failure

WithdrawnNCT00372762

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sHeart Failure

Start: 2011-01-31End: 2013-06-30Updated: 2014-03-27

Bumetanide Versus Furosemide in Heart Failure

WithdrawnNCT00372762

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sHeart Failure

Start: 2011-01-31End: 2013-06-30Updated: 2014-03-27

Efficiency of Bumetanide in Autistic Children

CompletedNCT01078714

University Hospital, BrestAutistics Children

Start: 2010-03-31End: 2011-06-30Updated: 2011-12-21

Role of Bumetanide in Treatment of Autism

RecruitingNCT04766177

Sherief Abd-ElsalamAutism

Start: 2021-01-01End: 2030-12-01Target: 80Updated: 2021-02-23

Bumetanide vs. Furosemide in Cirrhosis

Not yet recruitingNCT06941415

Stacy JohnsonCirrhosis

Start: 2026-03-01End: 2029-03-31Target: 500Updated: 2025-10-30

Phase 4

Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts

RecruitingNCT06218199

Heart Center Research, LLCHeart Failure, Congestive

Start: 2021-07-08End: 2026-12-31Target: 80Updated: 2024-01-29

Unknown Phase

Diuretic/Cool Dialysate Trial

TerminatedNCT02593526

University of New MexicoChronic Kidney Insufficiency

Start: 2017-01-31End: 2022-05-27Updated: 2024-01-11

Related Papers

Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4–5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial

BMC Nephrology2022-09-204 citations

Interaction Between the Sodium‐Glucose–Linked Transporter 2 Inhibitor Dapagliflozin and the Loop Diuretic Bumetanide in Normal Human Subjects

Journal of the American Heart Association2018-02-12132 citations

Neonatal seizures and disruption to neurotransmitter systems

Neural Regeneration Research2017-01-0117 citations

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.

2015-03-10181 citations