Artemether/Lumefantrine

DRUG13 trials

Conditions

HIVHIV InfectionsInstantaneous ClearanceMalariaMalaria PaediatricsMalaria Pregnancy and Childbirth

Phase 1

Pharmacokinetic Interactions Between Antiretroviral Agents and Antimalarial Drug Combinations

CompletedNCT00697892

Fran AweekaHIV Infections, Malaria

Start: 2005-07-31End: 2010-12-31Updated: 2013-06-06

Interaction Between Etravirine or Darunavir/Ritonavir and Artemether / Lumefantrine

CompletedNCT01876966

Janssen Pharmaceutica N.V., BelgiumHIV

Start: 2011-03-31End: 2011-07-31Updated: 2013-06-13

A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)

CompletedNCT06294912

Merck Sharp & Dohme LLCMalaria

Start: 2024-04-18End: 2025-01-06Updated: 2025-01-13

Phase 3

Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria

CompletedNCT01374581

Universiteit AntwerpenMalaria

Start: 2012-05-31End: 2014-06-30Updated: 2014-10-22

Phase 4

Ototoxicity of Artemether / Lumefantrine (Coartem) and Other Antimalarials

CompletedNCT00451139

Jimma UniversityMalaria

Updated: 2007-03-23

Artemether/Lumefantrine and Nevirapine Interaction Study in HIV-infected Adults

CompletedNCT00790881

University of Cape TownHIV, Malaria

Start: 2008-10-31End: 2009-12-31Target: 36Updated: 2010-06-28

Pharmacokinetic Interaction Between the Antimalarial Combination Artemether/Lumefantrine and Combination Antiretroviral Therapy Including Lopinavir/Ritonavir in HIV-infected Adults

CompletedNCT00869700

University of Cape TownHIV Infections, Malaria

Start: 2009-06-30End: 2010-02-28Updated: 2010-06-28

Parasite Clearance Time and Time to Recurrent Infection Following Treatment With Artemether/Lumefantrine

CompletedNCT01998295

Muhimbili University of Health and Allied SciencesInstantaneous Clearance

Start: 2012-05-31End: 2012-07-31Updated: 2014-03-18

Ivermectin-artemisinin Combination Therapy for Eradication of Malaria

NCT05605925

Makerere UniversityMalaria

Start: 2022-08-04End: 2022-12-31Target: 138Updated: 2022-11-04

Unknown Phase

ACT SENSITIVITY SURVEILLANCE IN KENYA [retrospectively registered]

RecruitingPACTR201111000316370

Malaria Paediatrics

Start: 2010-03-01Target: 466Updated: 2026-01-27

ARTEMETHER-LUMEFANTRINE VERSUS ARTESUNATE- AMODIAQUINE IN PREGNANT WOMEN

Active, not recruitingPACTR201310000484185

Ukah Chukwuemeka MarcelMalaria Pregnancy and Childbirth

Start: 2013-01-17Target: 150Updated: 2026-01-27

Efficacy of antimalarials (Artemether/Lumefantrine and Dihydroartemisinine/Piperaquine) used in Burkina Faso for the treatment of malaria in children

Active, not recruitingPACTR201708002499311

Improving Malaria Care (IMC Project)Malaria

Start: 2017-09-11Target: 720Updated: 2026-01-27

Clinical Investigation Study to Evaluate the Consistency and Reproducibility of Two Consecutive Mosquito Feeding Assays

CompletedNCT04666350

PATHMalaria

Start: 2021-03-09End: 2021-12-20Updated: 2024-04-29

2025-05-16

Anti-malarial efficacy and resistance monitoring of artemether-lumefantrine and dihydroartemisinin-piperaquine shows inadequate efficacy in children in Burkina Faso, 2017–2018

Malaria Journal2021-01-1993 citations

Prevalence of and Risk Factors Associated with Polymerase Chain Reaction-Determined Plasmodium falciparum Positivity on Day 3 after Initiation of Artemether–Lumefantrine Treatment for Uncomplicated Malaria in Bagamoyo District, Tanzania

American Journal of Tropical Medicine and Hygiene2019-03-1218 citations

Efficacy and safety of re-treatment with the same artemisinin-based combination treatment (ACT) compared with an alternative ACT and quinine plus clindamycin after failure of first-line recommended ACT (QUINACT): a bicentre, open-label, phase 3, randomised controlled trial.

2016-11-1115 citations

Uncomplicated Clinical Malaria Features, the Efficacy of Artesunate-Amodiaquine and Their Relation with Multiplicity of Infection in the Democratic Republic of Congo

PLoS ONE2016-06-0922 citations

The interaction between artemether-lumefantrine and lopinavir/ritonavir-based antiretroviral therapy in HIV-1 infected patients

BMC Infectious Diseases2015-12-0131 citations

A randomized trial of artesunate‐amodiaquine versus artemether‐lumefantrine for the treatment of acute uncomplicated malaria in pregnancy

International Journal of Gynecology & Obstetrics2015-07-0310 citations

Efficacy and safety of artemether-lumefantrine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children aged less than five years: results of an open-label, randomized, single-centre study.

2014-01-2842 citations

Impact of retreatment with an artemisinin-based combination on malaria incidence and its potential selection of resistant strains: study protocol for a randomized controlled clinical trial.

2013-09-2311 citations