Malaria Paediatrics
Conditions
Sponsors
Kenya Medical Research Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Presentation to the Health facility with probable clinical malaria. 2. Presence of fever ¿ 37.50C (axillary) 3. Aged between 6 and 59 months, inclusive 4. Weight ¿ 5 kgs 5. Mono-infection with P.falciparum at an asexual parasite density of 1000 ¿ 200,000 parasites per ¿l in malaria 6. Not suffering from severe and complicated forms of malaria (according to WHO, 2000 classification) 7. Able to take drugs under study by the oral route 8. Parent or guardian gives an informed written consent to participate in study
Exclusion criteria
Exclusion criteria: 1. Severe and/or complicated malaria (WHO, 2000 classification), including severe anaemia (Hb ¿5 g/dl), two or more seizures in last 24 hrs and hyper-parasitaemia (parasites >200,000 ¿l). 2. General clinical condition calling for hospitalization 3. Evidence of concomitant infections/disease at the time of presentation 4. Past or present history of chronic illnesses or any other underlying illness that would compromise the diagnosis and evaluation of the response to the study drug 5. History of allergy to artemisinin, lumefantrine or piperaquine 6. Full treatment with other antimalarial drugs within the past 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The risk of PCR corrected parasitaemia following treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Adequate clinical and parasitological response (ACPR): | — |
Countries
Kenya
Contacts
Public ContactJohn Ongecha
Senior Research Officer
Outcome results
None listed