Alanine

DIETARY_SUPPLEMENT17 trials

Sponsors

National Center for Research Resources (NCRR), University of Oregon, The University of Texas Medical Branch, Galveston, Augusta University, Maastricht University Medical Center

Conditions

Alzheimer DiseaseAtherosclerosisCovid19Diet ModificationEffect of Chronic Leucine Supplementation on Glucose Homeostasis, Lipid Profile, Body Composition, and Muscle Mass and StrenghtEffect of iv Administration of GIP and AlanineFrail ElderlyFructose Intolerance

Early Phase 1

Glutathione in Mild Cognitive Impairment

Active, not recruitingNCT03493178

Baylor College of MedicineMild Cognitive Impairment

Start: 2018-04-19End: 2026-12-31Target: 60Updated: 2026-03-24

Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19

TerminatedNCT04703036

Baylor College of MedicineCovid19

Start: 2021-01-11End: 2023-03-31Updated: 2024-06-26

Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease

RecruitingNCT04740580

Baylor College of MedicineAlzheimer Disease

Start: 2022-02-15End: 2026-12-31Target: 52Updated: 2025-06-10

Phase 1

The Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals

RecruitingNCT06419686

University Hospital, Gentofte, CopenhagenEffect of iv Administration of GIP and Alanine

Start: 2024-01-01End: 2024-07-31Target: 10Updated: 2024-05-17

Unknown Phase

Gluconeogenesis in Very Low Birth Weight Infants Who Are Receiving Nutrition By Intravenous Infusion

National Center for Research Resources (NCRR)Hyperglycemia, Infant, Low Birth Weight

Start: 1999-10-31Target: 96Updated: 2005-06-24

Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation

CompletedNCT00760383

University of OregonOsteoarthritis

Start: 2008-06-30End: 2013-12-31Updated: 2014-12-04

Muscle Mass During Space Exploration

CompletedNCT00968344

The University of Texas Medical Branch, GalvestonMuscle Loss

Start: 2009-08-31End: 2015-04-30Updated: 2019-05-31

Investigation of Alanine in Fructose Intolerance: A Dose Ranging Study

Augusta UniversityFructose Intolerance

Start: 2007-09-30End: 2024-04-30Target: 100Updated: 2022-07-21

Effects of Citrulline on Gut Functioning During Excercise

Maastricht University Medical CenterGastrointestinal, Gut Damage, Hypoperfusion

Start: 2010-12-31End: 2012-02-29Target: 30Updated: 2011-11-08

Effects of Chronic Leucine Supplemetion on Glucose Homeostasis, Body Compositin, Muscle Mass and Strength of Healthy and Young Subjects

SuspendedNCT01496768

University of Sao PauloEffect of Chronic Leucine Supplementation on Glucose Homeostasis, Lipid Profile, Body Composition, and Muscle Mass and Strenght

Start: 2012-01-31End: 2013-02-28Target: 24Updated: 2013-02-25

Resistance Exercise Training and Amino Acid Leucine Supplementation in Frail Elderly Women

CompletedNCT01922167

McGill University Health Centre/Research Institute of the McGill University Health CentreFrail Elderly

Start: 2013-11-30End: 2018-12-17Updated: 2019-03-08

Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity

Rambam Health Care CampusAtherosclerosis, Diet Modification, Serum; Disease

Start: 2017-07-01End: 2018-05-01Target: 110Updated: 2017-06-08

Study of Arginine and Nitric Oxide in Patients With Diabetes

CompletedNCT03566524

Baylor College of MedicineKetosis Prone Diabetes

Start: 2018-07-01End: 2022-06-30Updated: 2022-07-29

Investigation of Supplemental L-alanine in the Management of Dietary Fructose Intolerance

Augusta UniversityFructose Intolerance

Start: 2014-01-07End: 2020-12-30Target: 65Updated: 2020-04-15

Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial

WithdrawnNCT06579391

University of California, IrvineLumbar Spinal Stenosis

Start: 2025-01-31End: 2026-07-31Updated: 2025-05-29

The Separate and Combined Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Subjects With and Without Type 1 Diabetes

Active, not recruitingNCT06881472

Asger Lund, MDType 1 Diabetes

Start: 2025-01-01End: 2026-01-16Target: 10Updated: 2026-01-09

Investigating the Acute Effects of Increasing Alanine Exposure in Healthy Participants

Not yet recruitingNCT07350512

Nicolai Jacob Wewer AlbrechtsenGlucagon, Glucose Metabolism

Start: 2026-01-20End: 2027-01-20Target: 15Updated: 2026-01-20

Related Papers

Mitochondrial Content, but Not Function, Is Altered With a Multimodal Resistance Training Protocol and Adequate Protein Intake in Leucine-Supplemented Pre/Frail Women

Frontiers in Nutrition2021-01-2213 citations

Leucine Supplementation Does Not Alter Insulin Sensitivity in Prefrail and Frail Older Women following a Resistance Training Protocol.

2019-06-0111 citations

Leucine partially protects muscle mass and function during bed rest in middle-aged adults.

2015-12-30119 citations

Essential amino acid supplementation in patients following total knee arthroplasty

Journal of Clinical Investigation2013-10-2599 citations