severe asthma exacerbation severe asthma exacerbation, vibrating mesh nebulizer, aerogen
Conditions
Interventions
Patient severe asthma exacerbation patient in ED
Intervention prospective randomized open label parallel group-controlled trial Vibrating mesh nebulizer
Comparison Jet nebulizer
Outcome percentage
Jet nebulizer,Vibrating mesh nebulizer
Sponsors
Routine To Research Unit (R2R)
Aerogen Ltd
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adults patients (age 18 years old and above) presenting with acute asthma exacerbation diagnosed by ED physician characterized by a progressive increase in shortness of breath, cough, wheezing or chest tightness1,2 2. Severe asthma exacerbation by meeting one of the following criteria a. Speak in phrase or lean forward or agitation b. Respiratory rate >30 breaths/min c. Accessory muscle used d. Pulse rate > 120 beats/min e. Room air oxygen saturation <90% f. Peak expiratory flow rate (PEFR) or FEV1 <50% of predicted or best value
Exclusion criteria
Exclusion criteria: 1.Documented diagnosis of asthma COPD overlap syndrome ACOS or bronchiectasis. 2.Respiratory failure requiring endotracheal intubation including any of the following: -Altered mental status -Severe air hunger -Cyanosis -Abdominal paradox -Progressive respiratory acidosis -Oxygen saturation less than 90 despite oxygen therapy by face mask -Cardiopulmonary arrest 3.Pulmonary edema on chest radiograph. 4.Requirement for high flow nasal cannula HFNC or non invasive ventilation NIV within the first hour after treatment initiation. 5.Unable to cooperate with pulmonary function testing. 6.Unable to provide written informed consent or declined study participation. 7.Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FEV1 at initial and 1 hour after intervention percentage change in FEV1 | — |
Secondary
| Measure | Time frame |
|---|---|
| PEFR, FEV1 at initial and 1,2,4 hours after intervention percentage change of PEFR, FEV1,modified borg dyspnea scale at initial and 1,2,4 hours after intervention modified borg dyspnea scale,respiratory support 24 hours after intervention HFNC (high flow nasal cannula), NIV (non-invasive ventilation) ,endotracheal intubation,ED length of stay ED discharge hour of ED stay,hospital length of stay end of hospital stay day of hospital stay,bronchodilator ED discharge dose of bronchodilator,cost analysis end of hospital stay total treatment cost | — |
Countries
Thailand
Contacts
Public ContactNattakarn Praphruetkit
Faculty of Medicine Siriraj Hospital
Outcome results
None listed