Performance of knee osteoarthritis patients based on Kellgren-Lawrence grading after high molecular weight Hyaluronic acid injection

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20260327009

Enrollment

192

Registered

2026-03-27

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Performance score and pain in knee osteoarthritis patients receiving hyaluronic acid injection in various severity Osteoarthritis (OA) knee Hyaluronic acid (HA) Intra-articular hyaluronic acid (IA-HA) High molecular weight (HMW) hyaluronic acid Kellgren and Lawrence (K-L) classification Visual analog scale (VAS) Patient-reported outcome measures (PROMs) Performance-based measures (PBMs).

Interventions

Knee osteoarthritis patient with Kellgren-Lawrence grade 1, confirmed by x-ray,Knee osteoarthritis patient with Kellgren-Lawrence grade 2, confirmed by x-ray,Knee osteoarthritis patient with Kellgren-

Treatment,Treatment,Treatment,Treatment

KL 1,KL 2,KL 3,KL 4

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age 50-80 years of age 2. Knee OA diagnosed by the criteria of the American College of Rheumatology and confirmed by radiological evidences 3. Pain score of > 30 mm on a 100-mm visual analog scale (VAS) after using oral medication for more than 6 months

Exclusion criteria

Exclusion criteria: 1. Secondary OA 2. Previous lower limb surgery within the last 6 months. 3. Have been treated with intraarticular HA injection for less than 12 months before the study. 4. Serious concomitant medical illness or major co-morbidity precluding aerobic exercise at 50-60%maximum heart rate or cannot walk 3 minutes continuously. 5. Bleeding tendency or using anticoagulant. 6. Major neurological conditions. 7. Inability to communicate or unwilling to give informed consent.

Design outcomes

Primary

Measure	Time frame
Pain on motion 6 months Visual analog scale	—

Secondary

Measure	Time frame
Pain on motion 1 year Visual analog scale,Performance-based measures (PBMs) 6 months, 1 year Five times sit to stand (5XSST) , Time up and go (TUG), 3-minute walk test (3MWT),Patient-reported outcome measures (PROMs) 6 months, 1 year Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index	—

Countries

Thailand

Contacts

Public ContactThanakrita Siripullop

Chulalongkorn university

thana.earthhh@gmail.com0851348524

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026