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Chewable gums for restoring salivary pH post Non-Sucrose Carbonated Drink exposure in young adults

Chewable gums for restoring salivary pH post Non-Sucrose Carbonated Drink exposure in young adults

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20250910004
Enrollment
40
Registered
2025-09-10
Start date
2025-06-06
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Change in Salivary Clearance rate on using three different chewable gums following exposure to a non-sucrose carbonated drink in young adults to prevent dental caries promotion and dental erosion due to low pH conditions. Non-sucrose carbonated drink, Salivary Clearance rate, Salivary pH, Prevention, Oral hygiene

Interventions

1 Recaldent CPP-ACP chewable gum available in the market will be chewed for 1 minute following exposure to a non-sucrose carbonated drink (20 ml kept for 30 seconds in the oral cavity) and the sal
Chewable gum (sugar-free) containing CPP-APC,Chewable Xylitol gums,Chewable Calcium tablets,Tap Water

Sponsors

Department of public Health Dentistry, MAIDS
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 26 Years

Inclusion criteria

Inclusion criteria: Males and females aged 18 to 26 years. Participants with fair Plaque index will be included.

Exclusion criteria

Exclusion criteria: 1. Patients with systemic or local conditions that may affect the study results or in which the exposure to carbonated drink is contraindicated will not be enrolled in the study. 2. Systemic conditions included diseases (e.g., diabetes mellitus, Sjogren syndrome, chronic kidney disease, arterial hypertension, etc.) and/or intake of medications (e.g., of antihypertensive, anti-acne, anticholinergic, and antiseizure medications, antidepressants, antihistamines, etc.) that may affect salivary parameters. 3. Local conditions included oral mucosa pathology as it may affect the salivation rate; moreover, the presence of any pathological lesions on the oral mucosa makes exposure to acidic beverages and any new oral care product unacceptable. 4. Patients undergoing orthodontic appliance treatment will be excluded, as it may alter salivation and affect oral hygiene. 5. Patients who underwent dental bleaching will be excluded as it makes exposure to acidic and coloured beverages undesirable.

Design outcomes

Primary

MeasureTime frame
minimal pH level and salivary clearance time after exposure to non-sucrose carbonated drink alone or followed by administration of studied chewing gums and tablets. Baseline (pre-exposure to non-sucrose carbonated drink), Immediately Post exposure to drink, within 10 minutes post exposure to drink, Every 5 minutes after intervention (Chewable gum or tablet) pH paper (0.1 sensitivity

Secondary

MeasureTime frame
Effect of oral hygiene status on salivary pH and Salivary clearance time following exposure to non-sucrose carbonated drink. Baseline Plaque index

Countries

India

Contacts

Public ContactAswini Y. Balappanavar

Maulana Azad Institute of Dental Sciences

phdaswini@gmail.com09560782003

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 10, 2026