Split-thickness skin graft donor site wounds are a common concern in reconstructive surgery, often associated with severe pain, delayed wound healing, and scarring. These wounds occur in patients undergoing skin grafting for burns, traumatic injuries, chronic ulcers, or surgical reconstruction. Effective management is essential to reduce pain, promote faster healing, and improve scar quality. Current treatments, such as paraffin-chlorhexidine gauze dressings, have limitations, including poor pai
Conditions
Interventions
The topical TAB solution was prepared fresh for each patient by combining tranexamic acid, adrenaline, and bupivacaine under sterile conditions. ,Standard treatment sites received soft paraffin with c
TAB Solution,ST
Sponsors
Nakornping Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients scheduled for split-thickness skin grafting 2. Patients with acute or chronic wounds requiring skin grafting 3. Patients able to provide informed consent 4. Patients with two donor sites of comparable size for intra-individual comparison 5. Patients with stable vital signs and hemodynamic status before surgery 6. Patients without contraindications to local anesthetics, hemostatic agents, or vasoconstrictors 7. Patients willing to comply with the study protocol, including follow-up assessments
Exclusion criteria
Exclusion criteria: 1. Known allergies to solution components 2. Pregnancy 3. Severe comorbidities (advanced heart failure, coagulopathy) 4. Type 2 diabetes with fasting blood glucose exceeding 250 mg/dL or HbA1C above 9% 5. Cirrhosis beyond Child A stage 6. Body mass index above 30 7. Inability to comply with the study protocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain Intensity 24, 48, 72, and 120 hours post-surgery Visual Analog Scale (VAS, 0-10) Visual Analog Scale (VAS, 0-10),Epithelialization Rate Days 10-14 post-surgery Digital photography analysis,Time to Complete Healing Measured until full epithelialization Number of days from surgery to 100 percent epithelialization | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic Parameters Every 15 minutes for 2 hours post-application Heart rate, systolic and diastolic blood pressure using bedside monito,Scar Quality 8 weeks post-surgery Vancouver Scar Scale (VSS),Adverse Events Throughout the study period, including follow-up Standardized adverse event reporting forms | — |
Countries
Thailand
Contacts
Public ContactPattana Ongkasuwan
Nakornping Hospital
Outcome results
None listed